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ProteomicsProteome profiling of RNF213 depleted cells reveals nitric oxide regulator DDAH1 antilisterial activity
RNF213 is a large, poorly characterized interferon-induced protein. Mutations in RNF213 are associated with predisposition for Moyamoya disease (MMD), a rare cerebrovascular disorder. Recently, RNF213 was found to have broad antimicrobial activity in vitro and in vivo, yet the molecular mechanisms b...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027130 | Pride
Human Nitric oxide Ddah1 Listeria monocytogenes Listeria Bacteria Rnf213 Infection 
ProteomicsE3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP
RNF213 is a giant E3 ubiquitin ligase and a major susceptibility factor of Moyamoya disease, a cerebrovascular disorder that can result in stroke or death. In the cell, RNF213 is involved in lipid droplet formation, lipotoxicity, hypoxia, and NF-κB signaling, but its exact function in these processe...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-08-18 | PXD025992 | Pride
Rnf213 ube2l3 abp 
ProteomicsMoyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism
RNF213 is the major susceptibility factor for Moyamoya disease, a progressive cerebrovascular disorder that often leads to brain stroke in adults and children. Characterization of disease-associated mutations has been complicated by the enormous size of RNF213. Here we present the cryo-EM structure ...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-24 | PXD018701 | Pride
Rnf213 Mouse E3-ligase 
GenomicsRNF213-associated urticarial lesions with hypercytokinemia
RNF213-associated urticarial lesions with hypercytokinemia
PRJNA713772 | ENA
GenomicsRoles of RNF213 in temporal resonse to palmitate in HeLa cells
Roles of RNF213 in temporal resonse to palmitate in HeLa cells
PRJNA1367668 | ENA
TranscriptomicsRoles of RNF213 in temporal resonse to palmitate in HeLa cells
We aimed to study roles of RNF213 in palmitate-induced signaling pathways using RNF213-knockout HeLa cells.
ORGANISM(S): Homo sapiens 
2026-08-10 | GSE310980 | GEO
TranscriptomicsRNF213-associated urticarial lesions with hypercytokinemia
Urticarial lesions are observed in both cutaneous and systemic disorders. Familial forms of urticarial syndromes are rare and can be encountered in systemic auto-inflammatory diseases. We investigated a large family with dominantly inherited chronic urticarial lesions associated with hypercytokinemi...
ORGANISM(S): Homo sapiens 
2022-07-01 | GSE168721 | GEO
TranscriptomicsGene expression in commercial human cerebral microvascular endothelial cells (hCMECs) line knock out or not for RNF213
To study the role of RNF213, we generated RNF213-deficient human cerebral microvascular endothelial cells by the CRISPR-Cas9 double nickase method and showed that RNF213 may be an important regulator of the blood-brain barrier permeability and homeostasis
ORGANISM(S): Homo sapiens 
2021-09-08 | GSE183603 | GEO
GenomicsIdentification of RNF213 as a potential suppressor of local invasion in intrahepatic cholangiocarcinoma
Identification of RNF213 as a potential suppressor of local invasion in intrahepatic cholangiocarcinoma
PRJNA987989 | ENA
GenomicsGene expression in commercial human cerebral microvascular endothelial cells (hCMECs) line knock out or not for RNF213
Gene expression in commercial human cerebral microvascular endothelial cells (hCMECs) line knock out or not for RNF213
PRJNA761392 | ENA
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