Sort   by:  
 Page size 
TranscriptomicsTranscriptome analysis in macrophages treated with type I interferon, heat-killed Listeria monocytogenes, or both.
To define the group of genes which is synergistically induced by cooperative activity of the type I interferon - activated Jak/STAT pathway and other pathways, we treated bone marrow-derived macrophages (BMDM) with heat-killed Listeria (hkL; non-STAT pathways activated), type I interferon alone (onl...
ORGANISM(S): Mus musculus 
2015-06-15 | E-MTAB-3015 | biostudies-arrayexpress
UnknownOutcomes of radiation integrated with T-cell–engaging bispecific antibodies in relapsed/refractory multiple myeloma
Not available
S-EPMC12927042 | biostudies-literature
TranscriptomicsTranscriptome analysis reveals a major impact of Tyk2 on the expression of interferon responsive and metabolic genes
Peritoneal macrophages of Tyk2-/- and wildtype (wt) mice were compared before and after six hours of LPS treatment. Interferon responsive genes are lower expressed in Tyk2-/- macrophages at the basal level, metabolic genes higher before, but even more after LPS treatment. cDNA from macrophages from ...
ORGANISM(S): Mus musculus 
2010-04-01 | E-GEOD-19733 | biostudies-arrayexpress
TranscriptomicsS100 calcium-binding proteins A8/A9 initiate the early inflammatory program in injured peripheral nerve
To shed light on the early processes of immune response to peripheral nerve injury, we first used genome-wide transcriptional profiling and bioinformatics (Ingenuity, NextBio) pathway analyses of the proximal (P; regenerating) and distal (D; degenerating) nerve stumps at day 1 in the sciatic nerve a...
ORGANISM(S): Rattus norvegicus 
2015-01-01 | E-GEOD-62282 | biostudies-arrayexpress
TranscriptomicsContribution of the STAT1alpha and STAT1beta isoforms to IFN-gamma mediated innate immunity
The transcription factor STAT1 is essential for interferon- (IFN) mediated protective immunity in humans and mice. Two splice isoforms of STAT1, STAT1M-NM-1 and STAT1M-NM-2, differ with regard to a C-terminal transactivation domain, which is absent in STAT1M-NM-2. Dimers of STAT1M-NM-2 are therefore...
ORGANISM(S): Mus musculus 
2014-04-04 | E-GEOD-48970 | biostudies-arrayexpress
GenomicsChIPseq profile of RNA polymerase (pol II), the p65 subunit of NFkB, STAT1 and STAT2 in bone marrow derived macrophages after treatment with IFNb, heat-killed Listeria monocytogenes (hkL), or both.
Using ChIP-Seq analysis we define genes induced in macrophages through synergistic transcriptional activation by NFkB and the IFNb-activated transcription factor ISGF3.
ORGANISM(S): Mus musculus 
2015-06-15 | E-MTAB-2972 | biostudies-arrayexpress
UnknownPost-Transplant Outcomes in High-Risk Compared with Non-High-Risk Multiple Myeloma: A CIBMTR Analysis.
Not available
S-EPMC5090978 | biostudies-literature
TranscriptomicsGenome-wide expression analysis demonstrates a dominant role of TLR4 for activation of human phagocytes by the alarmin MRP8
The alarmins myeloid-related protein (MRP) 8 and MRP14 are the dominant cytoplasmic proteins in phagocytes. After release by activated phagocytes extracellular MRP8/MRP14 complexes promote inflammation in many diseases, including infections, allergies, autoimmune diseases, rheumatoid arthritis or in...
ORGANISM(S): Homo sapiens 
2014-12-12 | E-GEOD-56681 | biostudies-arrayexpress
UnknownOlder patients with myeloma derive similar benefit from autologous transplantation.
Not available
S-EPMC4194262 | biostudies-literature
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
Sort   by:  
 Page size