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Transcriptomics3' mRNA-seq of human Ma-Mel-47 (melanoma) and Panc89 (PDAC) cells treated with the USP7 degraders NK266 and NK250, respectively, for 72 h.
3' mRNA-seq was used to study the effects of USP7 degradation by the degraders NK266 and NK250 on gene expression in a human melanoma and PDAC cell line, respectively.
ORGANISM(S): Homo sapiens 
2026-03-27 | E-MTAB-16302 | biostudies-arrayexpress
ProteomicsStructural and functional analysis of peptides derived from KEX2-processed repeat proteins in agaricomycetes using reverse genetics and peptidomics
Bioactivities of fungal peptides are of interest for basic research and therapeutic drug development. Some of these peptides are derived from “KEX2-processed repeat proteins” (KEPs), a recently defined class of precursor proteins that contain multiple peptide cores flanked by KEX2 protease cleavage ...
ORGANISM(S): Lentinula edodes Pleurotus ostreatus PC15 Coprinopsis cinerea AmutBmut pab1-1 Komagataella pastoris (Yeast) (Pichia pastoris) Pleurotus eryngii var. eryngii 
2022-10-25 | PXD036934 | Pride
Fungi Peptidomics Mascot Ms/ms database search Lentinula edodes Pleurotus ostreatus Coprinopsis cinerea Pleurotus eryngii 
TranscriptomicsGene expression profiling of liver biopsies from 21 chronic hepatitis C patients undergoing antiviral therapy
This dataset is part of the paper: Pegylated interferon-α regulates hepatic gene expression by transient activation of the Jak-STAT pathway; Dill MT et al; Journal of Clinical Investigation; in review Pegylated interferon-α (pegIFN-α) has replaced un-modified recombinant IFN-α for the treatment of c...
ORGANISM(S): Homo sapiens 
2014-01-30 | E-GEOD-48445 | biostudies-arrayexpress
UnknownAURORA A interacts with DICER and SETD2 to promote S-phase progression
Not available
S-SCDT-10_1038-S44319-026-00850-0 | biostudies-other
TranscriptomicsMany obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers
Background: The mechanisms of how genetic variants (SNPs) identified in genome-wide association studies act to influence body mass remain unknown for most of these SNPs, which continue to puzzle the scientific community. Recent evidence points to epigenetic and chromatin state of the genome to have ...
ORGANISM(S): Homo sapiens 
2015-09-17 | E-GEOD-73103 | biostudies-arrayexpress
UnknownComprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease.
Not available
S-EPMC5223092 | biostudies-literature
UnknownBiallelic Mutation of ARHGEF18, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration.
Not available
S-EPMC5294887 | biostudies-literature
UnknownTrans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.
Not available
S-EPMC5056636 | biostudies-literature
UnknownTelomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data.
Not available
S-EPMC5778012 | biostudies-literature
UnknownDe Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures.
Not available
S-EPMC6037130 | biostudies-literature
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