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ProteomicsStructure of a volume-regulated heteromeric LRRC8A/C channel
Volume-regulated anion channels participate in the cellular response to osmotic swelling. These membrane proteins are heteromers of LRRC8 family members whose composition determines permeation properties. Although structures of the obligatory LRRC8A subunit have previously defined the architecture o...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-01-03 | PXD035350 | Pride
Lrrc8 Cryo-em Affinity purification Prm Human X-ray chrystallography Exploris 480 Volume-regulated anion channels Nanobody 
ProteomicsCryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation
Members of the leucine-rich repeat-containing 8 (LRRC8) protein family, composed of the five LRRC8A-E isoforms, are pore-forming components of the volume-regulated anion channel (VRAC), which is activated by cell swelling and transports halide anions and small organic compounds. Despite the recent a...
ORGANISM(S): Homo sapiens (Human) 
2020-05-27 | PXD018780 | Pride
Lrrc8d 
GenomicsThe volume-regulated anion channel LRRC8 is involved in initiation of epidermal differentiation and is deregulated in psoriasis
The volume-regulated anion channel LRRC8 is involved in initiation of epidermal differentiation and is deregulated in psoriasis
PRJNA1221294 | ENA
GenomicsThe volume regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING-p53 signaling
The volume regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING-p53 signaling
PRJNA687046 | ENA
ProteomicsStructural basis for malate-driven, pore lipid-regulated activation of the Arabidopsis vacuolar anion channel ALMT9.
In plant cells, the ALMTs are key plasma and vacuolar membranes anion channels regulating plant responses to the environment. Vacuolar ALMTs control stomata aperture and anion accumulation in guard cells. The activation of vacuolar ALMTs is voltage and malate dependent, but the underlying mechanisms...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-03-04 | PXD059651 | Pride
Almt9 Lipid Lc-ms/ms 
UnknownStructure of the human volume regulated anion channel.
Not available
S-EPMC6086657 | biostudies-literature
TranscriptomicsThe volume-regulated anion channel LRRC8 is involved in initiation of epidermal differentiation and is deregulated in psoriasis
Recent studies have shown that LRRC8A, the essential subunit of the volume-regulated anion channel LRRC8, which is responsible for mediating cell volume regulation during hypotonic stress, is predominantly localized in the basal layer of the epidermis. This prompted us to investigate whether LRRC8A ...
ORGANISM(S): Homo sapiens 
2025-02-09 | GSE289090 | GEO
GenomicsDeficient LRRC8A-dependent Volume-Regulated Anion Channel (VRAC) activity is associated with male infertility in mouse and humans
Deficient LRRC8A-dependent Volume-Regulated Anion Channel (VRAC) activity is associated with male infertility in mouse and humans
PRJNA448855 | ENA
UnknownMolecular determinants underlying volume-regulated anion channel subunit-dependent oxidation sensitivity.
Not available
S-EPMC9540897 | biostudies-literature
TranscriptomicsThe volume regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING-p53 signaling
The volume-regulated anion channel (VRAC) is a hexameric complex formed by LRRC8 proteins. VRACs are responsible for the regulatory volume decrease (RVD) after hypotonic cell swelling by mediating the efflux of chloride. Besides chloride, LRRC8 proteins transport other molecules including immunomodu...
ORGANISM(S): Mus musculus 
2021-12-31 | GSE163679 | GEO
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