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UnknownNAA60 facilitates LRRC8A- and LRRC8D-mediated platinum drug uptake.
Not available
S-EPMC12501270 | biostudies-literature
UnknownLoss of the volume-regulated anion channel components LRRC8A and LRRC8D limits platinum drug efficacy.
Not available
S-EPMC7613873 | biostudies-literature
UnknownCryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation.
Not available
S-EPMC7229184 | biostudies-literature
ProteomicsCryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation
Members of the leucine-rich repeat-containing 8 (LRRC8) protein family, composed of the five LRRC8A-E isoforms, are pore-forming components of the volume-regulated anion channel (VRAC), which is activated by cell swelling and transports halide anions and small organic compounds. Despite the recent a...
ORGANISM(S): Homo sapiens (Human) 
2020-05-27 | PXD018780 | Pride
Lrrc8d 
UnknownSubunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs.
Not available
S-EPMC4687416 | biostudies-literature
UnknownLateral Ventricular Neural Stem Cells Provide Negative Feedback to Circuit Activation Through GABAergic Signaling.
Not available
S-EPMC11940892 | biostudies-literature
UnknownCryoEM structure of human LRRC8D
Not available
EMPIAR-10383 | biostudies-other
TranscriptomicsTranscription profiling of human T lymphoblasts by IL-2 withdrawal ro determione the molecular signature of induced cell cycle exit
Molecular mechanisms of cell cycle exit are poorly understood. A group of genes required for cell cycle exit and maintenance of cell quiescence in human fibroblasts following serum deprivation has been recently identified. Studies on lymphocytes following growth factor deprivation-induced cell cycle...
ORGANISM(S): Homo sapiens 
2009-08-23 | E-GEOD-13909 | biostudies-arrayexpress
ProteomicsThe M1 aminopeptidase NPEPPS is a novel regulator of cisplatin sensitivity
Platinum-based chemotherapeutics are used in many combination regimens in cancer. Despite extensive use across diverse cancer types, there is room for improved efficacy and patient selection for treatment. Here, we use bladder cancer to address both issues. A multi-omic assessment of five human blad...
ORGANISM(S): Homo sapiens (Human) 
2024-02-20 | PXD024742 | Pride
Dna repair Lrrc8a Lrrc8d Tosedostat Volume regulated anion channel Synthetic lethality Transcriptomics Bladder cancer Genomics Chemotherapy Vrac Crispr screen Npepps Proteomics Cisplatin 
UnknownLRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion.
Not available
S-EPMC5958052 | biostudies-literature
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