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GenomicsThe M1 aminopeptidase NPEPPS is a novel regulator of cisplatin sensitivity
The M1 aminopeptidase NPEPPS is a novel regulator of cisplatin sensitivity
PRJNA719913 | ENA
UnknownNPEPPS Is a Druggable Driver of Platinum Resistance.
Not available
S-EPMC11094426 | biostudies-literature
ProteomicsThe M1 aminopeptidase NPEPPS is a novel regulator of cisplatin sensitivity
Platinum-based chemotherapeutics are used in many combination regimens in cancer. Despite extensive use across diverse cancer types, there is room for improved efficacy and patient selection for treatment. Here, we use bladder cancer to address both issues. A multi-omic assessment of five human blad...
ORGANISM(S): Homo sapiens (Human) 
2024-02-20 | PXD024742 | Pride
Dna repair Lrrc8a Lrrc8d Tosedostat Volume regulated anion channel Synthetic lethality Transcriptomics Bladder cancer Genomics Chemotherapy Vrac Crispr screen Npepps Proteomics Cisplatin 
TranscriptomicsThe M1 aminopeptidase NPEPPS is a novel regulator of cisplatin sensitivity
Platinum-based chemotherapeutics are used in many combination regimens in cancer. Despite extensive use across diverse cancer types, there is room for improved efficacy and patient selection for treatment. Here, we use bladder cancer to address both issues. A multi-omic assessment of five human blad...
ORGANISM(S): Homo sapiens 
2023-12-31 | GSE171537 | GEO
GenomicsThe M1 aminopeptidase NPEPPS is a novel regulator of cisplatin sensitivity. CRISPR Synthetic Lethal Screen.
The M1 aminopeptidase NPEPPS is a novel regulator of cisplatin sensitivity. CRISPR Synthetic Lethal Screen.
PRJNA745099 | ENA
OtherThe M1 aminopeptidase NPEPPS is a novel regulator of cisplatin sensitivity. CRISPR Synthetic Lethal Screen.
Platinum-based chemotherapeutics are used in many combination regimens in cancer. Despite extensive use across diverse cancer types, there is room for improved efficacy and patient selection for treatment. Here, we use bladder cancer to address both issues. A multi-omic assessment of five human blad...
ORGANISM(S): Homo sapiens 
2023-12-31 | GSE179799 | GEO
UnknownCD8+ T and NK cells characterized by upregulation of NPEPPS and ABHD17A are associated with the co-occurrence of type 2 diabetes and coronary artery disease.
Not available
S-EPMC10921359 | biostudies-literature
TranscriptomicsHuman patient tumor-derived organoid characterization from bladder cancer patients that did not respond to chemotherapy
A total of 3 independently derived organoids were compared to patient tumor samples and patient normal samples to determine if the tumor-derived organoids represent the genomic landscape of the tumor from which they were derived.
ORGANISM(S): Homo sapiens 
2023-01-02 | E-MTAB-10353 | biostudies-arrayexpress
Unknown<i>NPEPPS</i> segmental duplication drives position effect expression of <i>TBC1D3</i> in the human brain.
Not available
S-EPMC12871316 | biostudies-literature
UnknownRegulation of volume-regulated anion channels alters sensitivity to platinum chemotherapy.
Not available
S-EPMC11641020 | biostudies-literature
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