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GenomicsCell volume controlled by LRRC8A-formed volume-regulated anion channels fine-tunes T cell activation and function
Cell volume controlled by LRRC8A-formed volume-regulated anion channels fine-tunes T cell activation and function
PRJNA1018950 | ENA
ProteomicsStructure of a volume-regulated heteromeric LRRC8A/C channel
Volume-regulated anion channels participate in the cellular response to osmotic swelling. These membrane proteins are heteromers of LRRC8 family members whose composition determines permeation properties. Although structures of the obligatory LRRC8A subunit have previously defined the architecture o...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-01-03 | PXD035350 | Pride
Lrrc8 Cryo-em Affinity purification Prm Human X-ray chrystallography Exploris 480 Volume-regulated anion channels Nanobody 
OtherCell volume controlled by LRRC8A-formed volume-regulated anion channels fine-tunes T cell activation and function
To become fully functional effector T cells, naïve T cells undergo a drastic metabolic status shift from quiescence to substantial biosynthesis. The synthesis of biomass initiated by T cell receptor (TCR) signals drives the cell volume increase during T cell activation (T lymphoblast), which resembl...
ORGANISM(S): Mus musculus 
2023-09-23 | GSE243574 | GEO
UnknownLRRC8/VRAC volume-regulated anion channels are crucial for hearing.
Not available
S-EPMC11260850 | biostudies-literature
UnknownLRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength.
Not available
S-EPMC4733249 | biostudies-literature
UnknownRecent advances in structural characterization of volume-regulated anion channels (VRACs).
Not available
S-EPMC12333906 | biostudies-literature
UnknownInteractomic exploration of LRRC8A in volume-regulated anion channels.
Not available
S-EPMC11193767 | biostudies-literature
UnknownBiophysics and Structure-Function Relationships of LRRC8-Formed Volume-Regulated Anion Channels.
Not available
S-EPMC6451053 | biostudies-literature
UnknownStructural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels.
Not available
S-EPMC10480491 | biostudies-literature
UnknownSphingosine-1-phosphate activates LRRC8 volume-regulated anion channels through Gβγ signalling.
Not available
S-EPMC12333907 | biostudies-literature
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