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ProteomicsEndosomal cAMP production impacts the broad cellular phosphoproteome
Endosomal signaling from G protein-coupled receptors (GPCRs) has emerged as a novel paradigm with important pharmacological and physiological implications. Yet, our knowledge of the functional consequences of activating intracellular GPCRs is incomplete. To address this gap, we combined an optogenet...
ORGANISM(S): Homo sapiens (Human) 
2021-06-15 | PXD025775 | Pride
Camp- cyclic amp  bpac- bacterial photoactivatable adenylyl cyclase Gpcr- g protein-coupled receptor  silac- stable isotope labeling with amino acids in cell culture  fe3+-nta imac- iron (iii)-nitrilotriacetic acid immobilized metal ion affinity  lc-ms/ms- liquid chromatography-tandem mass spectrometry  pka- protein kinase a  pde- phosphodiesterase  pp2a- protein phosphatase 2a 
UnknownSpatial organization of adenylyl cyclase and its impact on dopamine signaling in neurons.
Not available
S-EPMC11436756 | biostudies-literature
UnknownSpatial decoding of endosomal cAMP signals by a metastable cytoplasmic PKA network.
Not available
S-EPMC8084946 | biostudies-literature
UnknownA Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action.
Not available
S-EPMC6481295 | biostudies-literature
ProteomicsAn Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells - B2AR_localization
SRM assays were generated for selected interactors of B2AR and DOR (MSV000084857), as well as for localization controls and ribosomal proteins (RPL18A, RPL28, RPL3, RPL35A, RPL6) as internal controls for normalization (Table S5 in publication). We selected localization markers for different cellular...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-02-17 | MSV000084967 | MassIVE
ProteomicsAn Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells - B2AR_DOR
SRM assays were generated for selected interactors of B2AR and DOR(MSV000084857), as well as for localization controls and ribosomal proteins (RPL18A, RPL28, RPL3, RPL35A, RPL6) as internal controls for normalization (Table S5 in publication). SRM assay generation was performed using Skyline. For al...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-02-17 | MSV000084966 | MassIVE
UnknownA Discrete Presynaptic Vesicle Cycle for Neuromodulator Receptors.
Not available
S-EPMC7035187 | biostudies-literature
UnknownAn expanded palette of dopamine sensors for multiplex imaging in vivo.
Not available
S-EPMC8169200 | biostudies-literature
ProteomicsA method for spatially and temporally resolved protein network interrogation in living cells
Cells operate through protein interaction networks organized in space and in time, but current methods to interrogate such biology typically resolve only one of these dimensions. Here, we describe a method to resolve both dimensions simultaneously using proximity labeling mediated by engineered asco...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-29 | MSV000084857 | MassIVE
ProteomicsProfiling the diversity of agonist-selective effects on the proximal proteome environment of G protein-coupled receptors
G-protein coupled receptors (GPCRs) regulate various aspects of cellular behavior and represent actionable targets for drug discovery. Activation of specific signaling pathways downstream of G-protein coupled receptors (GPCRs) or targeting the receptors at selected cellular locations has the potenti...
ORGANISM(S): Homo Sapiens 
2024-03-31 | PXD031393 | panorama
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