Sort   by:  
 Page size 
ProteomicsAberrant neurodevelopment in human iPS cell-derived models of Alexander disease
Alexander disease (AxD) is a rare, severe neurodegenerative disorder caused by mutations in the glial fibrillary acidic protein (GFAP). While the exact disease mechanism remains unknown, existing studies suggest that the mutant GFAP influences many cellular processes, including cytoskeleton stabilit...
ORGANISM(S): Homo sapiens (Human) 
2024-09-09 | PXD048606 | Pride
Scrna-seq Alexander disease Gfap Ips cells Brain organoids 
ProteomicsDivergent Cysteines in FOXO3 and FOXO4 Mediate Paralog-Specific Redox Signaling
Reduction-oxidation (redox) signaling, the translation of an oxidative intracellular environment into a cellular response, is mediated by the reversible oxidation of specific cysteine thiols. The latter results in disulfide formation between protein (hetero)dimers that alter protein function until t...
ORGANISM(S): Homo sapiens (Human) 
2014-08-26 | PXD001018 | Pride
Foxo cysteine-dependent interactors 
ProteomicsDivergent Cysteines in FOXO3 and FOXO4 Mediate Paralog-Specific Redox Signaling
Reduction-oxidation (redox) signaling, the translation of an oxidative intracellular environment into a cellular response, is mediated by the reversible oxidation of specific cysteine thiols. The latter results in disulfide formation between protein (hetero)dimers that alter protein function until t...
ORGANISM(S): Homo sapiens (Human) 
2014-08-26 | PXD001040 | Pride
Foxo3 human redox 
ProteomicsDivergent Cysteines in FOXO3 and FOXO4 Mediate Paralog-Specific Redox Signaling
Reduction-oxidation (redox) signaling, the translation of an oxidative intracellular environment into a cellular response, is mediated by the reversible oxidation of specific cysteine thiols. The latter results in disulfide formation between protein (hetero)dimers that alter protein function until t...
ORGANISM(S): Homo sapiens (Human) 
2014-08-26 | PXD001041 | Pride
Foxo3 reduction-oxidation (redox) signaling 
ProteomicsQuantitative proteomics of the SMAD transcription factor family reveals IPO5 as a BMP Receptor-SMAD specific importin
Gene-specific transcription factors (GSTFs) control of gene transcription by DNA binding and specific protein complex recruitment, which regulates promoter accessibility for transcription initiation by RNA polymerase II. GSTFs that are frequently mutated in colon and rectal carcinomas are Suppressor...
ORGANISM(S): Homo sapiens (Human) 
2016-10-10 | PXD004529 | Pride
Transcription regulation Proteomics Smad transcription factor Mass spectrometry Nuclear translocation 
ProteomicsComprehensive Profiling of Mammalian Tribbles Interactomes Implicates TRIB3 in Gene Repression
The three human Tribbles (TRIB) pseudokinases have been implicated in a plethora of signaling and metabolic processes linked to cancer initiation and progression and can potentially be used as biomarkers of disease and prognosis. While their modes of action reported so far center around protein–prot...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD030404 | Pride
Tribbles  proteomics  interactome  breast cancer 
ProteomicsHsa-miR-31-5p controls a metabolic switch in psoriatic keratinocytes that identifies therapeutic intervention
Next to genetic alterations, it is being recognized that the cellular environment also acts as a major determinant in onset and progression of disease. In cases where different cell types contribute to the final disease outcome, this imposes environmental challenges as different cell types likely di...
ORGANISM(S): Homo sapiens (Human) 
2023-02-06 | PXD029030 | Pride
Mir-31metabolism psoriasis keratinocytes 
ProteomicsCysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16INK4A
p16INK4A inhibits the CDK4/6 kinases and is therefore an important cell cycle regulator. Accumulation of p16INK4A in response to oncogenic transformation leads to cellular senescence and it is therefore frequently lost in cancer. p16INK4A is also known to accumulate under conditions of cellular oxid...
ORGANISM(S): Homo sapiens (Human) 
2019-09-04 | PXD012353 | Pride
Cysteine oxidation amyloid fibril p16ink4a 
ProteomicsFER drives tumor progression cues of invasive breast cancer cells through kinase-dependent control of proliferation and endosomal recycling
Triple-Negative Breast Cancer (TNBC) is a poorly targetable cancer subtype that exhibits a high metastatic potential. To develop new intervention strategies, it is crucial to understand the mechanisms governing migratory and invasive features of TNBC cells. Previously it was shown that high expressi...
ORGANISM(S): Homo sapiens (Human) 
2022-04-15 | PXD021307 | Pride
Analogue-sensitive Cell invasion Endosomal recycling. Breast cancer Fer tyrosine kinase Proliferation 
ProteomicsTrib3 modulates PPAR-mediated growth inhibition by interfering with the MLL complex in breast cancer cells
Dysregulation of pathways due to mutations on oncogenes or tumor suppressors that leads to aberrant expression or activity of proteins is the most well understood mechanism that drives cancer initiation and progression. TRIB3, a member of the Tribbles family of pseudokinases, is often found dysregul...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD036341 | Pride
Mll complex Breast cancer cells Trib3 Ppar 
Sort   by:  
 Page size