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ProteomicsRab5a-VPS34 unnatural amino acid mediated crosslinking
The small GTPase Rab5 has an essential role in sorting vesicles arriving to and leaving the early endosome. One key function of Rab5 in this process is the activation of the primordial phosphatidylinositol 3-kinase VPS34, a lipid kinase that phosphorylates phosphatidylinositol (PI) to generate PI3P....
ORGANISM(S): Homo Sapiens (human) 
2021-12-21 | PXD023533 | JPOST Repository
ProteomicsUbiquitinated sites on VPS34 by UBE3C LC-MSMS
Ubiquitinated sites on VPS34 identified by LC-MS/MS analysis of VPS34 derived from in vivo ubiquitination assays of UBE3C-transfected or -untransfected 293T cells.
ORGANISM(S): Homo sapiens (Human) 
2021-02-19 | PXD023959 | Pride
Vps34 Ubiquitinated sites Ube3c 
ProteomicsAntileukemic activity of the VPS34-IN1 inhibitor in acute myeloid leukemia
Acute myeloid leukemia (AML) is an aggressive disease with a poor prognosis. Vacuolar protein sorting 34 (VPS34) is a member of the phosphatidylinositol-3-kinase lipid kinase family that controls the canonical autophagy pathway and vesicular trafficking. Using a recently developed specific inhibitor...
ORGANISM(S): Homo sapiens (Human) 
2020-11-11 | PXD016839 | Pride
Vps34-in1 Autophagy L-asparaginase Vps34 Human molm-14 cells Orbitrap fusion Aml 
ProteomicsUbiquitin chain types on ubiquitinated VPS34 in the presence or absence of UBE3C in vitro LC-MSMS
We identified VPS34 as the direct substrate of UBE3C E3 ligase in vivo and in vitro. Next, to analyze the ubiquitin chain on VPS34 that was assembled by UBE3C in vitro.
ORGANISM(S): Homo sapiens (Human) 
2021-02-17 | PXD023986 | Pride
Ubiquitin chain types Vps34 Ube3c 
ProteomicsLack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development
Regulatory T (Treg) cells are essential for the maintenance of immunological tolerance, yet the molecular components required for their maintenance and effector functions remain incompletely defined. Inactivation of VPS34 in Treg cells led to an early, lethal phenotype, with massive effector T cell ...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-29 | PXD048981 | Pride
Mouse Vps34 Pi3k T cells T regs 
ProteomicsA novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolution
RAB5-GTP activation of the multiprotein VPS34 complex II (VPS34-CII) is critical for endosomal sorting and maturation, phagocytosis, and receptor downregulation. RAB5-GTP activates VPS34-CII, by binding to a helical insertion in the C2 domain of VPS34 on the BECLIN1/UVRAG-containing adaptor arm of t...
ORGANISM(S): Homo sapiens (Human) 
2026-05-26 | PXD061277 | Pride
ProteomicsLong noncoding RNA BCRP3 stimulates VPS34 and autophagy activities to promote protein homeostasis and cell survival
Background: Autophagy plays important roles in cell homeostasis and protein quality control. Long non-coding RNAs (lncRNAs) have been revealed as an emerging class of autophagy regulators, but the majority of them function in regulating the expression of autophagy-related genes. LncRNAs that directl...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030756 | Pride
Autophagy Vps34 complex Protein quality control Tgf- signaling Lncrna Cell death. 
GenomicsDistinct Vps34-orchestrated signaling processes dictate the transitional heterogeneity and functional adaptation of effector Treg cells [scMultiomics]
Distinct Vps34-orchestrated signaling processes dictate the transitional heterogeneity and functional adaptation of effector Treg cells [scMultiomics]
PRJNA1192970 | ENA
GenomicsDistinct Vps34-orchestrated signaling processes dictate the transitional heterogeneity and functional adaptation of effector Treg cells [scRNAseq]
Distinct Vps34-orchestrated signaling processes dictate the transitional heterogeneity and functional adaptation of effector Treg cells [scRNAseq]
PRJNA1192971 | ENA
GenomicsVPS34 regulates RAB7 activation and Retromer localization to autophagosomes and mitophagy in oocytes
VPS34 regulates RAB7 activation and Retromer localization to autophagosomes and mitophagy in oocytes
PRJNA893662 | ENA
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