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ProteomicsUbiquitinated sites on VPS34 by UBE3C LC-MSMS
Ubiquitinated sites on VPS34 identified by LC-MS/MS analysis of VPS34 derived from in vivo ubiquitination assays of UBE3C-transfected or -untransfected 293T cells.
ORGANISM(S): Homo sapiens (Human) 
2021-02-19 | PXD023959 | Pride
Vps34 Ubiquitinated sites Ube3c 
ProteomicsUbiquitin chain types on ubiquitinated VPS34 in the presence or absence of UBE3C in vitro LC-MSMS
We identified VPS34 as the direct substrate of UBE3C E3 ligase in vivo and in vitro. Next, to analyze the ubiquitin chain on VPS34 that was assembled by UBE3C in vitro.
ORGANISM(S): Homo sapiens (Human) 
2021-02-17 | PXD023986 | Pride
Ubiquitin chain types Vps34 Ube3c 
OtherCRISPR-Cas9 Screening Identifies UBE3C as a Top Negative Regulator of THEMIS Protein Expression
THEMIS is an essential T-cell receptor signal modulator critical for T-cell development and peripheral homeostasis; however, the machinery governing its protein stability remains elusive. Utilizing unbiased CRISPR/Cas9 screening integrated with affinity purification-mass spectrometry, we identify UB...
ORGANISM(S): Homo sapiens 
2026-04-30 | GSE322555 | GEO
GenomicsCRISPR-Cas9 Screening Identifies UBE3C as a Top Negative Regulator of THEMIS Protein Expression
CRISPR-Cas9 Screening Identifies UBE3C as a Top Negative Regulator of THEMIS Protein Expression
PRJNA1430406 | ENA
ProteomicsTemporal control of acute protein aggregate turnover by UBE3C and NRF1-dependent proteasomal pathways
A hallmark of neurodegenerative diseases such as Parkinson’s Disease is the progressive loss of proteostasis, leading to the conversion of misfolded proteins into aggregates and subsequent cytotoxicity. To combat this toxicity, cells have evolved degradation pathways (ubiquitin-proteasome system and...
ORGANISM(S): Homo sapiens (Human) 
2024-10-09 | PXD055227 | Pride
Ubiquitin-proteasome system Nrf1 Protein quality control Protein aggregates Protein turnover Ube3c 
UnknownUBE3C tunes autophagy via ATG4B ubiquitination.
Not available
S-EPMC10936621 | biostudies-literature
UnknownOncogenic UBE3C promotes breast cancer progression by activating Wnt/β-catenin signaling.
Not available
S-EPMC7789303 | biostudies-literature
UnknownRecurrent UBE3C-LRP5 translocations in head and neck cancer with therapeutic implications.
Not available
S-EPMC10912599 | biostudies-literature
UnknownUbiquitin ligase UBE3C promotes melanoma progression by increasing epithelial-mesenchymal transition in melanoma cells.
Not available
S-EPMC4941273 | biostudies-literature
UnknownThe E3 ubiquitin ligase UBE3C enhances proteasome processivity by ubiquitinating partially proteolyzed substrates.
Not available
S-EPMC3843071 | biostudies-literature
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