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ProteomicsER-trafficking triggers NRF1 ubiquitination to promote its proteolytic activation
The endoplasmic reticulum (ER) is a multifaceted organelle that plays an essential role in cellular processes such as protein folding, modification, and trafficking. It also acts as a proteostasis sensor and contributes to adaptation responses to maintain cellular homeostasis. The transcription fact...
ORGANISM(S): Homo sapiens (Human) 
2023-09-05 | PXD041331 | Pride
Erad Ubiquitination Nrf1 Ddi2 Proteostasis 
TranscriptomicsRibo-Seq analysis of Col-0, nrf1-1 and nrf1-2 mutant under Fe sufficient and Fe deficiency condition
This study will reveal the importance of nrf1 in revealing the translational control of Fe homeostasis
ORGANISM(S): Arabidopsis thaliana 
2019-12-30 | E-MTAB-8158 | biostudies-arrayexpress
ProteomicsHuman Nrf1 interactome upon proteasome inhibition
Nuclear factor erythroid-derived 2 related factor 1 (NFE2L1/Nrf1), an endoplasmic reticulum (ER)-associated transcription factor, is responsible for the coordinated expression of proteasome subunit genes upon proteasomal dysfunction. N-glycosylated proteins undergo protein sequence editing by peptid...
ORGANISM(S): Homo sapiens (Human) 
2025-12-14 | PXD065838 | Pride
Nrf1 Proteasome 
GenomicsCompetition between DNA methylation and transcription factors determines binding of NRF1
Eukaryotic transcription factors (TFs) are key determinants of gene activity, yet they bind only a fraction of their corresponding DNA sequence motifs in any given cell type. Chromatin has the potential to restrict accessibility of binding sites; however, in which context chromatin states are instru...
ORGANISM(S): Homo sapiens 
2015-12-16 | E-GEOD-67867 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of Col-0 and nrf1-2 mutant under Fe sufficient and Fe deficiency condition
This study will reveal the importance nrf1-2 in controlling the Fe homeostasis network under iron deficiency
ORGANISM(S): Arabidopsis thaliana 
2019-12-30 | E-MTAB-8157 | biostudies-arrayexpress
ProteomicsAbsolute quantification analysis of ubiquitin chains attached to Nrf1 purified from NGLY1-KO cells overexpressing Nrf1-FLAG with HA-FBS2.
We examined ubiquitin-linkages on Nrf1 purified from cell lysates of NGLY1-KO cells overexpressing Nrf1-FLAG with HA-FBS2. The ubiquitin linkage types were quantified using the LC-MS/MS-based absolute quantification method, ubiquitin parallel reaction monitoring (Ub-AQUA/PRM).
ORGANISM(S): Homo sapiens (Human) 
2024-08-06 | PXD053753 | Pride
Nrf1 Ubiquitination Fbs2 
TranscriptomicsComparison of gene expression profiles among Nrf1 liver-specific conditional knockout, Nrf2 knockout and Keap1 knockdown mice.
To identify Nrf1-dependent and Nrf2-dependent genes in the liver, we examined the gene expression profiles of Nrf1 Alb-CKO, Nrf2 knockout and Keap1 knockdown mouse livers by microarray analyses. Total RNAs from Nrf1dN/-::Alb-Cre, Nrf1dN/+, Nrf2-/-, Nrf2+/+, Keap1KD/- and Keap1KD/+ mouse livers were ...
ORGANISM(S): Mus musculus 
2012-05-17 | E-GEOD-35124 | biostudies-arrayexpress
GenomicsAnalysis of binding of the transcriptional factor Nrf1 in mouse embryonic stem cells
Analysis of binding of the transcriptional factor Nrf1 in mouse embryonic stem cells by ChIP-Seq
ORGANISM(S): Mus musculus 
2017-12-15 | E-MTAB-3475 | biostudies-arrayexpress
TranscriptomicsDetection of transcription factor NRF1, YY1 and SP1 bound regions in human peripheral blood monocytes
To study the correlation between sequence motif appearance, transcription factor binding and aberrant hypermethylation in the cell lines, we performed ChIP-on-chip analyses (on CpG island microarrays) for the transcription factors Sp1, NRF1 and YY1 in normal peripheral blood monocytes. Keywords: Ch...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-16078 | biostudies-arrayexpress
GenomicsChIP-seq of NRF1 in skeletal muscle
ChIP-seq of NRF1 in skeletal muscle
PRJNA1060641 | ENA
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