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ProteomicsHuman DDI2 is a ubiquitin-directed endo-protease
The Ddi1/DDI2 proteins are classified as ubiquitin shuttling factors and are implicated in a wide range of cellular functions. In addition to ubiquitin-binding and ubiquitin-like domains, these proteins contain a conserved region with similarity to retroviral proteases, but whether and how they func...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018215 | Pride
Human Silac Ddi2 Ubiquitin 
ProteomicsDDI2 is a ubiquitin-directed endoprotease, responsible for cleavage of transcription factor NRF1
The Ddi1/DDI2 proteins are ubiquitin shuttling factors, implicated in a variety of cellular functions. In addition to ubiquitin-binding and ubiquitin-like domains, they contain a conserved region with similarity to retroviral proteases, but whether and how DDI2 functions as a protease has remained u...
ORGANISM(S): Homo sapiens (Human) 
2020-06-24 | PXD019152 | Pride
Ubisite Prm Ddi2 Ubiquitin Hph Lc-ms/ms 
ProteomicsTMT proteomics dataset comparing control vs. DDI2-knockout cells
Comparison of control vs DDI2-knockout cells using TMT proteomics
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD060474 | Pride
Ddi2 
TranscriptomicsThe protease DDI2 regulates NRF1-metallothionein pathway in response to Cadmium toxicity in the liver
DNA-damage inducible 1 homolog 2 (DDI2) is an aspartic protease that cleaves and activates the transcription factor NRF1. Cellular models have shown that this pathway contributes to cell-stress adaption, for example, upon proteasome inhibition. However, DDI2 physiological function is unknown. Ddi2 K...
ORGANISM(S): Mus musculus 
2022-10-19 | GSE198150 | GEO
GenomicsDDI2-dependent genes ONX-0914 immune cells
Comparative transcriptomic analysis of DDI2-deficient THP-1 cells vs Control THP-1 cells upon challenge with selective immunoproteasome inhibitor
PRJEB114398 | ENA
GenomicsThe protease DDI2 regulates NRF1-metallothionein pathway in response to Cadmium toxicity in the liver
The protease DDI2 regulates NRF1-metallothionein pathway in response to Cadmium toxicity in the liver
PRJNA813869 | ENA
GenomicsDual regulation of chemical stress-induced DDI2/3 expression by a transcription factor Fzf1 and nucleosome in Saccharomyces cerevisiae
DDI2 and DDI3 (DDI2/3) are duplicated genes in Saccharomyces cerevisiae that exhibit strong induction by a transcription factor Fzf1 in response to chemical treatments like cyanamide (CY) and methyl methanesulfonate (MMS). Although, like DDI2/3, SSU1, YHB1 and YNR064C also contain an Fzf1-binding co...
ORGANISM(S): Saccharomyces cerevisiae 
2026-04-13 | GSE327798 | GEO
UnknownThe protease DDI2 regulates NRF1 activation in response to cadmium toxicity.
Not available
S-EPMC9557025 | biostudies-literature
UnknownDDI2 protease controls embryonic development and inflammation via TCF11/NRF1.
Not available
S-EPMC11424978 | biostudies-literature
GenomicsDual regulation of chemical stress-induced DDI2/3 expression by a transcription factor Fzf1 and nucleosome in Saccharomyces cerevisiae
Dual regulation of chemical stress-induced DDI2/3 expression by a transcription factor Fzf1 and nucleosome in Saccharomyces cerevisiae
PRJNA1452825 | ENA
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