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ProteomicsStudy of biological function of VRK1 in the development and progress of prostate cancer
VRK1 plays a significant role in the growth and drug resistance of prostate cancer.
ORGANISM(S): Homo Sapiens 
2024-11-22 | PXD058205 |
ProteomicsComparative interactomes of VRK1 and VRK3: implication in cell cycle, chromatin assembly, RNA processing and DNA repair
Vaccinia related kinase (VRK) family is a ser/threonine kinase. VRK1 and VRK3 are localized in the same organelle, mainly in the nucleus. Comparative interactomes of VRK1 and VRK3 were not performed yet. We identified over 200 unreported VRK1/3-interacting proteins by proteomics-based analyses using...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD004103 | Pride
Vrk1 Interactome Vrk3 
ProteomicsVRK1 regulates sensitivity to oxidative stress by altering the nuclear phosphoproteome and histone epigenetic modifications
Chromatin organization and its dynamic remodeling determine its accessibility and sensitivity to DNA damage. The major source of endogenous DNA damage is oxidative stress. We studied the role of the VRK1 chromatin kinase in the response to oxidative stress, which alters the nuclear phosphoproteome a...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD040944 | Pride
Methylation Acetylation Nuclear proteins Vrk1 Oxidative stress Phosphoproteomics Chromatin 
TranscriptomicsTranscriptome analysis of testicular cells in wild type (VRK1+/+) and mutant (VRK1-/-) Mus musculus
Transcriptome analysis of testicular cells in VRK1+/+ and VRK1-/- Mus musculus
ORGANISM(S): Mus musculus 
2013-11-21 | GSE19329 | GEO
TranscriptomicsTranscriptome analysis of testicular cells in wild type (VRK1+/+) and mutant (VRK1-/-) Mus musculus
Transcriptome analysis of testicular cells in VRK1+/+ and VRK1-/- Mus musculus Gene expression in whole testicular cells from wild type (VRK1+/+) and VRK1-/- mutant Mus musculus, respectively, was measured. Four independent experiment for wild type and mutant, respectively, were performed.
ORGANISM(S): Mus musculus 
2013-11-21 | E-GEOD-19329 | biostudies-arrayexpress
ProteomicsVRK1 is required in VRK2-methylated cancers of the nervous system
Collateral lethality occurs when loss of one paralog renders cancer cells dependent on the remaining paralog. Combining genome scale CRISPR/Cas9 screens coupled with RNA-sequencing in over 900 cancer cell lines, we found that cancers of nervous system lineage, including adult and pediatric gliomas a...
ORGANISM(S): Homo sapiens (Human) 
2022-09-06 | PXD030599 | Pride
Phosphorylation 
GenomicsVRK1 phosphorylates SRRM2 for the regulation of splicing of DNA damage repair factors
VRK1 phosphorylates SRRM2 for the regulation of splicing of DNA damage repair factors
PRJNA1492088 | ENA
ProteomicsVRK1 knockdown phospho and total proteomics
To understand the effects of VRK1 knockdown on global phospho- and total- proteomics we profiled the U251MG VRK2-low and VRK2-high cell lines at 5- and 7-days post-doxycycline treatment.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-07-01 | MSV000089783 | MassIVE
GenomicsVRK1 is a Novel Therapeutic Target for Small Cell Neuroendocrine Carcinoma of the Cervix
VRK1 is a Novel Therapeutic Target for Small Cell Neuroendocrine Carcinoma of the Cervix
PRJNA1207445 | ENA
TranscriptomicsGene expression profiling in VRK1-deficient testis of Mus musculus
To study effect of VRK1 deletion on spermatogenesis of the mouse, transciptomic analysis of genes in postnatal 8-day testicular cells of wild type and VRK1-deficient Mus musculus was performed.
ORGANISM(S): Mus musculus 
2011-12-30 | GSE22674 | GEO
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