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TranscriptomicsPBMC Cell Subset Stimulation
PBMC cell subsets were treated with 0.6 pM IFNg for 0-24h and compared to mock-treated time series. Abstract: Background Interferons are key modulators of the immune system, and are central to the control of many diseases. The response of immune cells to stimuli in complex populations is the produc...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-16253 | biostudies-arrayexpress
TranscriptomicsGene expression programs in PBMCs elicited by 6 major mediators of the immune response.
Abstract: Background Interferons are key modulators of the immune system, and are central to the control of many diseases. The response of immune cells to stimuli in complex populations is the product of direct and indirect effects, homotypic and heterotypic cell interactions. Dissecting the global...
ORGANISM(S): Homo sapiens 
2010-03-21 | E-GEOD-17762 | biostudies-arrayexpress
TranscriptomicsPBMC Cytokine Comparison
Treatment of PBMC with 0.6 pM cytokine from 0-24h Abstract: Background Interferons are key modulators of the immune system, and are central to the control of many diseases. The response of immune cells to stimuli in complex populations is the product of direct and indirect effects, homotypic and he...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-16251 | biostudies-arrayexpress
TranscriptomicsPBMC IFNg Dose Reponse
PBMC response to three concentrations of IFNg (0.006, 0.6 and 60 pM) from 0-12h. Abstract: Background Interferons are key modulators of the immune system, and are central to the control of many diseases. The response of immune cells to stimuli in complex populations is the product of direct and ind...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-16252 | biostudies-arrayexpress
TranscriptomicsMethionine Sulfoximine Resistance in Mycobacterium tuberculosis Is Due to a Single Nucleotide Deletion Resulting in Increased Expression of the Major Glutamine Synthetase, GlnA1.
We investigated the effect of methionine sulfoximine (MetSox), a potent inhibitor of glutamine synthetase, on Mycobacterium tuberculosis. M. tuberculosis encodes four glutamine synthetases, of which MetSox targets the type I enzyme encoded by glnA1. Trancriptional profiling revealed that glutamate s...
ORGANISM(S): Mycobacterium tuberculosis 
2011-09-06 | E-BUGS-112 | biostudies-arrayexpress
TranscriptomicsPain-killer carprofen elicits pleiotropic modes of bactericidal action with potential to reverse antimicrobial resistance in tuberculosis.
The alarming rise of antimicrobial resistance in Mycobacterium tuberculosis coupled with the shortage of new antibiotics has made tuberculosis (TB) control a global health priority. Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the growth of multi-drug resistant isolates of M. tuberculosis....
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2020-08-15 | E-MTAB-6191 | biostudies-arrayexpress
TranscriptomicsFat, lazy and indifferent - profiling persistent drug-tolerant tubercule bacilli from patient sputa during treatment predicts drug efficacy
Amplified M.tb RNA derived from 15 subjects at multiple time intervals before and during chemotherapy (totalling 52 samples) was profiled alongside M.tb H37Rv RNA extracted from in vitro log phase bacilli (2 biological replicates hybridised in duplicate) as a standardised comparator. Amplified mycob...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2016-04-12 | E-MTAB-3872 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of defined Mycobacterium tuberculosis populations using RNA amplification strategies
Background The amplification of bacterial RNA is required if complex host-pathogen interactions are to be studied where the recovery of bacterial RNA is limited. Here, using a whole genome Mycobacterium tuberculosis microarray to measure cross-genome representation of amplified mRNA populations, we ...
ORGANISM(S): Mycobacterium tuberculosis 
2008-03-12 | E-BUGS-42 | biostudies-arrayexpress
TranscriptomicsThree-dimensional low shear culture of Mycobacterium bovis BCG induces biofilm formation and antimicrobial drug tolerance
Mycobacteria naturally grow as corded biofilms in liquid media without detergent. Such detergent-free biofilm phenotypes may reflect the growth pattern of bacilli in tuberculous lung lesions. New strategies are required to treat tuberculosis that is responsible for more deaths each year than any oth...
ORGANISM(S): Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2 
2021-01-29 | E-MTAB-9904 | biostudies-arrayexpress
TranscriptomicsDissecting the Mycobacterium bovis BCG response to macrophage infection to identify targets for anti-tuberculosis drug and vaccine discovery
New strategies are required to reduce the worldwide burden of tuberculosis. Intracellular survival and replication of Mycobacterium tuberculosis after macrophage phagocytosis is a fundamental step in the complex host-pathogen interactions that lead to granuloma formation and disease. Greater underst...
ORGANISM(S): Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2 
2022-01-14 | E-MTAB-11107 | biostudies-arrayexpress
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