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ProteomicsProteomic analysis of GBA iPSC-dopamine neurons
Heterozygous mutations in the glucocerebrosidase gene (GBA) are the strongest common genetic risk factors for Parkinson’s disease (PD) present in around 5-10% of PD patients, resulting in lower age of onset and exacerbating disease progression, including an increased risk of dementia. However, the e...
ORGANISM(S): Homo sapiens (Human) 
2023-03-04 | PXD026691 | Pride
Neuritogenesis/parkinson’s/proteomics/stem cells/glucocerebrosidase/post-translational modification 
TranscriptomicsSingle cell sequencing of iPSC-dopamine neurons reconstructs disease progression and identifies HDAC4 as a regulator of Parkinson cell phenotypes
Induced pluripotent stem cell (iPSC)-derived dopamine neurons provide an opportunity to model Parkinson’s disease (PD) but neuronal cultures are confounded by cellular heterogeneity. By applying high-resolution single cell transcriptomic analyses to Parkinson’s iPSC-derived dopamine neurons carrying...
ORGANISM(S): Homo sapiens 
2018-10-17 | E-MTAB-7303 | biostudies-arrayexpress
TranscriptomicsSNP data from induced Pluripotent Stem cells from Parkinson's Disease patients harbouring G2019S mutations in the LRRK2 gene
We have generated human induced Pluripotent Stem cells (hiPSc) using Retroviral virus-mediated delivery of reprogramming factors. hiPSc lines have been screened using SNP array to assess chromosomal stability (alongside the fibroblast lines from which they derived), and validation of the pluripotenc...
ORGANISM(S): Homo sapiens 
2016-02-09 | E-GEOD-77662 | biostudies-arrayexpress
UnknownEffect of Four Hemoglobin Transfusion Threshold Strategies in Patients With Acute Myocardial Infarction and Anemia : A Target Trial Emulation Using MINT Trial Data.

Background

The optimal hemoglobin threshold to guide red blood cell (RBC) transfusion for patients with acute myocardial infarction (MI) and anemia is uncertain.

Objective

To estimate the efficacy of 4 individual hemoglobin thresholds (<10 g/dL [<100 g/L], <9 g/dL [<90 g/L], <8 g/dL [...
S-EPMC12701713 | biostudies-literature
UnknownRestrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia.

Background

A strategy of administering a transfusion only when the hemoglobin level falls below 7 or 8 g per deciliter has been widely adopted. However, patients with acute myocardial infarction may benefit from a higher hemoglobin level.

Methods

In this phase 3, interventional trial,...
S-EPMC10837004 | biostudies-literature
UnknownUsing CSF biomarkers to replicate genetic associations in Alzheimer's disease.
Defining cases and controls on the basis of biomarkers rather than clinical diagnosis may reduce sample sizes required for genetic studies. The aim of this study was to assess whether characterizing case/control status on the basis of cerebrospinal fluid (CSF) profile would increase power to replica...
S-EPMC3150628 | biostudies-literature
UnknownReducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries.

Background

Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.

Methods

This study adopted a four-phase Delphi consensus co-prioritizati...
S-EPMC10364528 | biostudies-literature
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