Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia.

ABSTRACT:

Background

A strategy of administering a transfusion only when the hemoglobin level falls below 7 or 8 g per deciliter has been widely adopted. However, patients with acute myocardial infarction may benefit from a higher hemoglobin level.

Methods

In this phase 3, interventional trial, we randomly assigned patients with myocardial infarction and a hemoglobin level of less than 10 g per deciliter to a restrictive transfusion strategy (hemoglobin cutoff for transfusion, 7 or 8 g per deciliter) or a liberal transfusion strategy (hemoglobin cutoff, <10 g per deciliter). The primary outcome was a composite of myocardial infarction or death at 30 days.

Results

A total of 3504 patients were included in the primary analysis. The mean (±SD) number of red-cell units that were tr

SUBMITTER: Carson JL 

PROVIDER: S-EPMC10837004 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature