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TranscriptomicsPseudomonas aeruginosa two-component regulator BfmR controls bacteriophage lysis and DNA release during biofilm development through PhdA
Biofilms are surface-adhered bacterial communities encased in an extracellular matrix composed of polysaccharides, proteins, and extracelluar (e)DNA, with eDNA being required for the formation and integrity of biofilms. Here we demonstrate that the spatial and temporal release of eDNA is regulated b...
ORGANISM(S): Pseudomonas aeruginosa 
2011-06-01 | E-GEOD-28953 | biostudies-arrayexpress
TranscriptomicsMicrocolony formation by the opportunistic pathogen Pseudomonas aeruginosa requires pyruvate and pyruvate fermentation.
A hallmark of the biofilm architecture is the presence of microcolonies. However, little is known about the underlying mechanisms governing microcolony formation. In the human pathogen Pseudomonas aeruginosa, microcolony formation is dependent on the two-component regulator MifR, with mifR mutant bi...
ORGANISM(S): Pseudomonas aeruginosa 
2012-04-30 | E-GEOD-35286 | biostudies-arrayexpress
TranscriptomicsIn vitro effect of the integrine LAMA4 on motility and cluster formation of human chondrocytes
Background: Cluster formation of hypertrophic chondrocytes is a sign of late stage osteoarthritis. In vitro chondrocytes have the ability to migrate on scaffolds. Important for motility issues in cartilage are integrines, part of the extracellular matrix, important for locomotory stimuli. The integr...
ORGANISM(S): Homo sapiens 
2015-12-22 | E-GEOD-68428 | biostudies-arrayexpress
TranscriptomicsIdentification of bone morphogenetic protein (BMP)-7 as a key instructive factor for human epidermal Langerhans cell differentiation and proliferation
Langerhans dendritic cells represent abundantly occuring and evolutionary highly conserved DCs specifically located in the stratified epithelial tissues. LCs are unique among DC family members in that they express epithelial-type adhesion molecules, allowing them to form a tight three-dimensional ne...
ORGANISM(S): Homo sapiens 
2013-10-18 | E-GEOD-49085 | biostudies-arrayexpress
TranscriptomicsRNA expression analysis in a multigeneration feeding study of OF1 outbred mice
To analyze the effect of different aliments, male OF1 mice were fed ad libitum with a custom-made diet containing 33% maize derived from three cultivars containing comparable nutritional values for multiple generations. To evaluate possible effects on the gene expression in the small intestine, the...
ORGANISM(S): Mus musculus 
2013-02-20 | E-GEOD-44396 | biostudies-arrayexpress
TranscriptomicsMurine hepatocellular carcinoma of AlbLTa/b transgenic mice and age matched C57BL/6 mice - 18 months old.
aCGH analysis of murine transgenic liver tissues affected with HCC, hybridized with age (18 months) and sex matched C57BL/6 mice. Moreover, 18months old C57BL/6 livers were hybridized with independent 18 months old C57BL/6 livers for control. Keywords: Array comparative genomic hybridization analy...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-14467 | biostudies-arrayexpress
MetabolomicsGNPS - Effect of rumen-protected methionine on metabolic profile in liver, muscle and blood serum samples of growing German Simmental bulls at restricted protein supply
This study aimed to determine the metabolic response of growing Fleckvieh bulls fed diets low in crude protein (CP) supplemented with rumen-protected methionine (RPM). In total, 69 bulls were assigned to three dietary treatments (n=23/group): Positive control (CON; 13.7% CP; 2.11 g methionine/kg DM...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) 
2023-07-07 | MSV000092367 | GNPS
ProteomicsCRISPR/dCAS9 genomic engineering for boosting the therapeutic potential of Extracellular Vesicles
This study aimed to enhance the therapeutic effect of MSC-derived extracellular vesicles (EVs) by overexpressing the TSG-6 gene using CRISPR activation and evaluate the biological activity of these modified EVs on human intervertebral disc (IVD) cells in vitro. n immortalized human MSC line was tran...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD060381 | Pride
Human Mscs Extracellular vesicles Crispr 
TranscriptomicsGene expression in hypoxic non-small cell lung cancer
Hypoxia triggers aggressive cancer growth and contributes to chemotherapy resistance. Novel therapeutic strategies aim at targeting hypoxia activated signaling pathways. Tumor hypoxia not only affects neoplastic tumor cells but also the surrounding stroma cells. Therefore, a novel ex vivo model was ...
ORGANISM(S): Homo sapiens 
2011-07-27 | E-GEOD-30979 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse hematopoetic progenitor cells with Flk12+ Ncad-, Flk12- Ncad+, Flk12+ Ncad+ or Flk12- Ncad- phenotypes
N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells
ORGANISM(S): Mus musculus 
2008-01-04 | E-TABM-404 | biostudies-arrayexpress
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