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ProteomicsPhosphorylation of Cyclin F at Serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(Cyclin F) complex.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder that is characterized by progressive weakness, paralysis and cachexia often resulting in patient death within 3-5 years of diagnosis. Recently, we identified mutations to the CCNF gene, which encodes the Cyclin F protein, in c...
ORGANISM(S): Homo sapiens (Human) 
2017-12-08 | PXD004531 | Pride
Als Phosphorylation Ubiquitylation E3 ligase 
UnknownStructure of a catalytic dimer of the α- and β-subunits of the F-ATPase from Paracoccus denitrificans at 2.3 A resolution.
Not available
S-EPMC4601596 | biostudies-literature
UnknownPositron Emission Tomography Imaging of Staphylococcus aureus Infection Using a Nitro-Prodrug Analogue of 2-[18F]F-p-Aminobenzoic Acid.
Not available
S-EPMC7429255 | biostudies-literature
TranscriptomicsIn vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs
Dicer is an RNase III-family endoribonuclease and haploinsufficient tumor suppressor that is required for the biogenesis of miRNAs, yet in vivo structure-function characterization of its RNase IIIA and IIIB domains have not been reported. In murine Dicer knockout fibroblasts, we expressed human Dic...
ORGANISM(S): Mus musculus 
2012-07-13 | E-GEOD-36978 | biostudies-arrayexpress
UnknownOrganization of Subunits in the Membrane Domain of the Bovine F-ATPase Revealed by Covalent Cross-linking.
Not available
S-EPMC4505582 | biostudies-literature
ProteomicsMutations to the ALS/FTD gene CCNF reveals elevated Lys48-linked ubiquitination by the SCF(cyclin F) complex
Approximately 10% of Amyotrophic lateral sclerosis (ALS) cases have a positive family history (familial ALS) and appear clinically indistinguishable from sporadic cases. ALS and frontotemporal dementia (FTD) are fatal neurodegenerative disorders that have common molecular and pathogenic characterist...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-01 | PXD002011 | Pride
Motor neurone disease Als Ccnf Ubiquitin 
UnknownBinding of the inhibitor protein IF(1) to bovine F(1)-ATPase.
Not available
S-EPMC3041923 | biostudies-literature
UnknownCasein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex.
Not available
S-EPMC5666078 | biostudies-literature
UnknownHow the regulatory protein, IF(1), inhibits F(1)-ATPase from bovine mitochondria.
Not available
S-EPMC1994141 | biostudies-literature
UnknownGenomic network analysis of environmental and livestock F-type plasmid populations.
Not available
S-EPMC8319146 | biostudies-literature
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