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ProteomicsExpression of ALS-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, fatal neurodegenerative disease characterised by the loss of upper and lower motor neurons. Approximately 10% of ALS cases have a known family history of the disease and mutations in multiple genes have been identified. ALS-linked mutatio...
ORGANISM(S): Mus musculus (Mouse) 
2017-05-22 | PXD005131 | Pride
Motor neurone disease Amyotrophic lateral sclerosis Zebrafish 
ProteomicsIdentification of CCNF/Cyclin F targets
The founding member of the F-box protein family, Cyclin F, serves as substrate adaptor for the Ubiquitin E3 ligase Skp1-Cul1-F-box (SCF)Cyclin F which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in CCNF encodin...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-09-13 | PXD030729 | Pride
Lc-ms Human Als Mouse Ccnf Cyclin f 
ProteomicsMutations to the ALS/FTD gene CCNF reveals elevated Lys48-linked ubiquitination by the SCF(cyclin F) complex
Approximately 10% of Amyotrophic lateral sclerosis (ALS) cases have a positive family history (familial ALS) and appear clinically indistinguishable from sporadic cases. ALS and frontotemporal dementia (FTD) are fatal neurodegenerative disorders that have common molecular and pathogenic characterist...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-01 | PXD002011 | Pride
Motor neurone disease Als Ccnf Ubiquitin 
UnknownCCNF is a potential pancancer biomarker and immunotherapy target.
Not available
S-EPMC10164972 | biostudies-literature
UnknownZebrafish CCNF and FUS Mediate Stress-Specific Motor Responses.
Not available
S-EPMC10930717 | biostudies-literature
UnknownCCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia.
Not available
S-EPMC4835537 | biostudies-literature
UnknownA Novel Signature of CCNF-Associated E3 Ligases Collaborate and Counter Each Other in Breast Cancer.
Not available
S-EPMC8228695 | biostudies-literature
UnknownScreening for CCNF Mutations in a Chinese Amyotrophic Lateral Sclerosis Cohort.
Not available
S-EPMC6034086 | biostudies-literature
UnknownGenetic and Phenotypic Spectrum of Amyotrophic Lateral Sclerosis Patients with CCNF Variants from a Large Chinese Cohort.
Not available
S-EPMC10224817 | biostudies-literature
UnknownOverexpression of cyclin F/CCNF as an independent prognostic factor for poor survival in clear cell renal cell carcinoma.
Not available
S-EPMC11039610 | biostudies-literature
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