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TranscriptomicsInhibitors that block initiation of wall teichoic acid biosynthesis sensitize methicillin-resistant Staphylococcus aureus to beta-lactams
Methicillin resistance in Staphylococcus aureus depends on the production of mecA, which encodes penicillin-binding protein 2A (PBP2A), an acquired peptidoglycan transpeptidase with reduced susceptibility to beta-lactam antibiotics. Here, we show that preventing the expression of wall teichoic acids...
ORGANISM(S): Staphylococcus aureus 
2010-10-19 | E-GEOD-24439 | biostudies-arrayexpress
ProteomicsAuxB interacts directly with GpsB and PknB to coordinate cell envelope processes that contribute to intrinsic antibiotic resistance in Staphylococcus aureus
Staphylococcus aureus, a leading cause of serious infections, produces various factors important for intrinsic resistance to antibiotics. Understanding what intrinsic resistance factors do may enable strategies to potentiate existing antibiotics. The membrane protein AuxB is an intrinsic resistance ...
ORGANISM(S): Staphylococcus aureus 
2025-08-25 | PXD065790 | Pride
Prka Prkc Pasta domain Staphylococcus aureus Serine/threonine kinases Cell wall Pknb Cell envelope Stkp Antibiotic resistance 
TranscriptomicsAn antibiotic that inhibits a late step in wall teichoic acid biosynthesis induces the cell wall stress stimulon in Staphylococcus aureus
Wall teichoic acids (WTAs) are phosphate-rich, sugar-based polymers attached to the cell walls of most Gram-positive bacteria. In Staphylococcus aureus, these anionic polymers regulate cell division, protect cells from osmotic stress, mediate host colonization, and mask enzymatically susceptible pep...
ORGANISM(S): Staphylococcus aureus 
2012-01-12 | E-GEOD-34441 | biostudies-arrayexpress
ProteomicsAspartate residues far from the active site drive O-GlcNAc transferase substrate selection
Here we use protein microarray technology and proteome-wide glycosylation profiling to show that conserved aspartate residues in the tetratricopeptide repeat (TPR) lumen of OGT drive substrate selection. Changing these residues to alanines alters substrate selectivity and unexpectedly increases rate...
ORGANISM(S): Homo sapiens (Human) 
2019-07-26 | PXD014731 | Pride
Glycoproteomics O-glcnac 
UnknownFunction and Emotion in Everyday Life With Type 1 Diabetes (FEEL-T1D): Protocol for a Fully Remote Intensive Longitudinal Study.
Not available
S-EPMC8544739 | biostudies-literature
TranscriptomicsHuman airway epithelial responses to rhinovirus infection and cigarette smoke extract alone and in combination
This study was performed to test the hypothesis that cigarette smoke extract would alter the responses of primary cultures of human bronchial epithelial cells to infection with purified human rhinovirus 16. The data show marked alterations in rhinovirus-induced expression profiles of a number of gen...
ORGANISM(S): Homo sapiens 
2011-03-15 | E-GEOD-27973 | biostudies-arrayexpress
UnknownGenome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
Not available
S-EPMC2719288 | biostudies-literature
GenomicsATD
WTCCC1 project Autoimmune Thyroid Disease (ATD) samples
EGAD00000000011 | EGA
GenomicsBC
WTCCC1 project Breast cancer (BC) samples
EGAD00000000013 | EGA
GenomicsMS
WTCCC1 project Multiple Sclerosis (MS) samples
EGAD00000000012 | EGA
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