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GenomicsInhibiton of the GABPB1L-containing GABP tetramer is sufficient to reverse replicative immortality in TERT promoter mutant glioblastoma cells.
Over 50 types of cancer acquire TERT promoter mutations. These single point mutations reactivate telomerase, allowing for indefinite maintenance of telomere length and enabling cellular immortalization. The transcription factor binding site created by the point mutations specifically recruit the ETS...
EGAS00001002582 | EGA
TranscriptomicsBiopsies from metastatic Clear Cell Renal Carcinoma before or after treatment with nivolumab
Tumor core needle biopsies from kidney or metastatic sites obtained at trial enrollment i.e. Screen and/or at Cycle 2 Day 8 (i.e.Week 4) from metastatic clear cell RCC patients treated with 0.2mpk, 3mpk or 10mpk (as 2nd or further line of therapy; Arms A,B,C) or 10mpk (as first line therapy; Arm D) ...
ORGANISM(S): Homo sapiens 
2016-05-15 | E-MTAB-3218 | biostudies-arrayexpress
UnknownPALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.
Not available
S-EPMC5200636 | biostudies-literature
UnknownLiraglutide and Cardiovascular Outcomes in Type 2 Diabetes.
Not available
S-EPMC4985288 | biostudies-literature
UnknownAssessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.
Not available
S-EPMC5340115 | biostudies-literature
UnknownPhenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study.
Not available
S-EPMC9359694 | biostudies-literature
UnknownFeatures of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study.
Not available
S-EPMC10764789 | biostudies-literature
UnknownCOPDGene® 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease.
Not available
S-EPMC7020846 | biostudies-literature
UnknownGenome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA.
Not available
S-EPMC4063682 | biostudies-literature
UnknownConsortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk.
Not available
S-EPMC4197821 | biostudies-literature
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