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UnknownERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway.
Not available
S-EPMC11116810 | biostudies-literature
TranscriptomicsSuv39h-dependent H3K9me3 represses intact retrotransposons in mouse embryonic stem cells
Heterochromatin is required to restrict aberrant expression of retrotransposons, but it remains poorly defined due to the underlying repeat-rich sequences. We dissected Suv39h-dependent histone H3 lysine 9 trimethylation (H3K9me3) by genome-wide ChIP-sequencing in mouse embryonic stem cells (ESCs). ...
ORGANISM(S): Mus musculus 
2014-06-26 | E-GEOD-57092 | biostudies-arrayexpress
TranscriptomicsTelomerase is a prognostic marker of poor outcome and a therapeutic target in neuroblastoma
The aim of this study is to determine the clinical relevance of telomerase activation versus ALT as biomarkers in pre-treatment neuroblastoma, and to assess the potential value of telomerase as a therapeutic target. Therefore, the genomic status of TERT and MYCN was assessed in 457 pretreatment neur...
ORGANISM(S): Homo sapiens 
2019-09-16 | E-MTAB-8248 | biostudies-arrayexpress
ProteomicsProtein interaction network analysis reveals growth conditions-specific crosstalk between chromosomal DNA replication and other cellular processes in E. coli
E. coli and many other bacterial species can alternate their cell cycle according to nutrient availability. As a result, they grow and divide very fast under optimal conditions or slow down the cell cycle when conditions deteriorate. This adaptability is underlined by mechanisms coordinating cell gr...
ORGANISM(S): Escherichia coli 
2022-03-03 | PXD030113 | Pride
Ap-ms E.coli Chromosmal dna 
UnknownDose-dense temozolomide for newly diagnosed glioblastoma: a randomized phase III clinical trial.
Not available
S-EPMC3816958 | biostudies-literature
ProteomicsQuantitative proteomics identifies ML111 as a cell-cycle inhibitor
We used quantitative mass spectrometry to analyze the effect of ML111 on the whole proteome of SK-N-MC cells. Results: ML111 treatment results in the accumulation of APC/C substrates suggesting that ML111 disrupts the cell cycle at or before the mitotic spindle assembly checkpoint.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-12-15 | MSV000086599 | MassIVE
UnknownEmpagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC10957483 | biostudies-literature
UnknownHigher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC11872607 | biostudies-literature
UnknownBaricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis.
Not available
S-EPMC9333998 | biostudies-literature
UnknownCasirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC8830904 | biostudies-literature
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