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ProteomicsRelating the equine « cumulome » to the developmental competence of the corresponding oocyte
In vitro maturation (IVM) of equine oocytes results in a reduced developmental capacity compared to in vivo matured oocytes. Cumulus cells mirror oocytal well-being through close bidirectional communication. After maturation, the cumulus complex is not required anymore. Therefore, these cells are a ...
ORGANISM(S): Equus caballus (Horse) 
2024-09-18 | PXD033551 | Pride
Cumulus Oocyte Ivf Equine Biomarker Proteomics Ivm 
ProteomicsThe bovine cumulus proteome of cumulus oocyte complexes that successfully matured or failed to mature after maturation in-vitro and in-vivo
The oocyte forms a complex with their somatic cumulus cells within the follicle throughout the preovulatory maturation steps. Cumulus cells support their oocyte not only through mechanical protection but also with a close bidirectional exchange of metabolites. Analysis of the oocytes cumulus gives t...
ORGANISM(S): Bos taurus (Bovine) 
2020-06-30 | PXD016679 | Pride
Cumulus Proteomics Oocyte 
ProteomicsAnalysis of the proteome of individual equine cumulus complexes after maturation in-vitro and in-vivo
Maturation of oocytes under in-vitro conditions (IVM) results in impaired developmental competence compared to oocytes matured in-vivo. Oocytes are closely coupled to their cumulus complex (COC) with a bidirectional exchange of metabolites. Therefore, elucidation of aberrations in cumulus metabolism...
ORGANISM(S): Equus caballus (Horse) 
2019-11-12 | PXD011086 | Pride
In-vitro Cumulus cells In-vivo Lc-ms/ms Ivm 
TranscriptomicsExpression data from mitochondrial protease ClpP knock-out mice.
The peptidase ClpP is conserved from bacteria to human. In the mitochondrial matrix, it multimerizes and forms a macromolecular proteasome-like cylinder. Because of its known relevance for the mitochondrial unfolded protein response during cell stress, we characterized two ClpP knock-out mouse found...
ORGANISM(S): Mus musculus 
2013-07-17 | E-GEOD-40207 | biostudies-arrayexpress
ProteomicsHSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B cell receptor signaling
Burkitt’s lymphoma (BL) is an aggressive B-cell neoplasm that is currently treated by intensive chemotherapy in combination with anti-CD20 antibodies. Because of their toxicity, current treatment regimens are often not suitable for elderly patients or for patients in developing countries where BL is...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080781 | MassIVE
UnknownEnhancer Hijacking Discovery in Acute Myeloid Leukemia by Pyjacker Identifies MNX1 Activation via Deletion 7q.
Not available
S-EPMC12209774 | biostudies-literature
UnknownNeural correlates of human fear conditioning and sources of variability in 2199 individuals.
Not available
S-EPMC12375119 | biostudies-literature
UnknownFour-Year Visual Outcomes in the Protocol W Randomized Trial of Intravitreous Aflibercept for Prevention of Vision-Threatening Complications of Diabetic Retinopathy.
Not available
S-EPMC10408259 | biostudies-literature
UnknownPlasma Vascular Endothelial Growth Factor Concentrations after Intravitreous Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema.
Not available
S-EPMC6568257 | biostudies-literature
UnknownAflibercept, bevacizumab, or ranibizumab for diabetic macular edema.
Not available
S-EPMC4422053 | biostudies-literature
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