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TranscriptomicsLinkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3
OBJECTIVE: MEIS1, a HOX cofactor, collaborates with multiple HOX and NUP98-HOX fusion proteins to accelerate the onset of acute myeloid leukemia (AML) through largely unknown molecular mechanisms. MATERIALS AND METHODS: To further resolve these mechanisms, we conducted a structure-function analysis ...
ORGANISM(S): Mus musculus 
2009-04-09 | E-GEOD-15541 | biostudies-arrayexpress
TranscriptomicsDICER1 hotspot mutations cause defective miRNA processing
Recurrent somatic hotspot mutations of DICER1 appear to be clustered around each of four critical metal binding residues in the RNase IIIB domain of DICER1. This domain is responsible for cleavage of the 3’ end of the 5p-miRNA strand of a pre-mRNA hairpin. To investigate the effects of these cancer-...
ORGANISM(S): Mus musculus 
2012-10-01 | E-GEOD-40965 | biostudies-arrayexpress
GenomicsDynamics of genomic clones in breast cancer patient xenografts at single cell resolution
Human cancers, including breast cancers, are comprised of clones differing in mutation content that evolve dynamically in space and time following principles of Darwinian evolution, underpinning important emergent features such as drug resistance and metastasis. Human breast cancer xenoengraftment i...
EGAS00001000952 | EGA
Genomicsena-DATASET-BCCA-13-11-2014-22:09:20:907-954 - samples
Dynamics of genomic clones in breast cancer patient xenografts at single cell resolution
EGAD00001001066 | EGA
GenomicsBC Cancer, part of the Provincial Health Services Authority, Technology Development Office, Data Access Committee (PHSA TDO DAC)
Access to data generated by BCCA is made available by completing the data access agreement for review by the data access committee and will be granted to qualified investigators for appropriate use.
EGAC00000000011 | EGA
TranscriptomicsComparative genomic hybridization study of Streptococcus pneumoniae
PFGRC has developed a cost effective alternative to complete genome sequencing in order to study the genetic differences between closely related species and/or strains. The comparative genomics approach combines Gene Discovery (GD) and Comparative Genomic Hybridization (CGH) techniques, resulting in...
ORGANISM(S): Streptococcus oralis SK255 
2011-07-31 | E-GEOD-29501 | biostudies-arrayexpress
TranscriptomicsProfiling transcriptional and translational response to anoxia or hypoxia of genes in DNA damage response and repair pathways in human fibroblast and prostate cancer cells using NanoString nCounter.
Identification of genes in DNA damage response and repair pathways differentially transcribed or translated under anoxia or hypoxia in GM05757 normal human fibroblast cells and DU145 human prostate cancer cells. Comparison of mRNA abundance and translation efficiency of genes in DNA damage response ...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-52461 | biostudies-arrayexpress
UnknownAVERT2 (a very early rehabilitation trial, a very effective reproductive trigger): retrospective observational analysis of the number of babies born to trial staff.
Not available
S-EPMC4676118 | biostudies-literature
UnknownExploring threats to generalisability in a large international rehabilitation trial (AVERT).
Not available
S-EPMC4550737 | biostudies-literature
UnknownPrespecified dose-response analysis for A Very Early Rehabilitation Trial (AVERT).
Not available
S-EPMC4898313 | biostudies-literature
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