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ProteomicsIntegrated Optoproteomics and AP-MS Reveals interactome Remodeling Upon NLRP3 Inflammasome Activation
NOD-like receptor family pyrin domain-containing 3 (NLRP3) is a critical intracellular danger sensor that forms inflammasome complexes to drive inflammatory caspase activation; however, the components and dynamic organization of the NLRP3 inflammasome remain incompletely defined. Here, we systematic...
ORGANISM(S): Mus Musculus 
2026-06-11 | PXD079555 |
ProteomicsA proximity labeling map of SARS-CoV-2 and human
The global epidemic caused by the coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in the infection of over 200 million people. To extend the knowledge of interactions between SARS-CoV-2 and humans, we systematically investigate the interactome of 29 viral protei...
ORGANISM(S): Homo Sapiens 
2022-01-06 | PXD022086 |
ProteomicsHRD1-ERAD controls production of the hepatokine FGF21 through CREBH polyubiquitination
As a ubiquitin ligase, HRD1 may regulate FGF21 expression through targeting protein degradation. We then aimed to identify proteins whose expressions are altered at post-transcriptional levels in HRD1 LKO mouse liver
ORGANISM(S): Mus Musculus 
2021-12-14 | PXD030410 |
ProteomicsER -associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes
Mass spectrometry characterization of the proteins in complex with endogenous HRD1 yielded a total of 347 proteins from three independent experiments
ORGANISM(S): Homo Sapiens 
2018-04-04 | PXD009402 |
ProteomicsA proximity interactome assay for interaction of nipah virus F and G protein with the cellular protein
Nipah virus (NiV) is a highly lethal zoonotic virus with a potential large-scale outbreak, which poses a great threat to world health and security. Cell entry is the first step in viral infection, and the entry of NiV into host cells is inseparable from the attachment (G) and fusion (F) glycoprotein...
ORGANISM(S): Homo Sapiens 
2023-12-22 | PXD048109 |
ProteomicsInteraction of species A rotavirus VP4 with the cellular proteins vimentin and actin related protein 2 discovered by a proximity interactome assay
Rotavirus (RV) is one of the most significant pathogens in humans and animals with diarrhea worldwide. Cell entry is the first step in viral infection, and the outer capsid protein VP4 is crucial for RV attachment and internalization. In order to discover novel candidate host factors involved in RV ...
ORGANISM(S): Homo Sapiens 
2023-10-07 | PXD045952 |
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