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ProteomicsIdentification of Unknown Biological Toxin Protein Using Mass Spectrometry: A Case Study on De Novo Sequencing of Ricin
Currently, the genomes of many toxin proteins remain unsequenced. Characterizing these toxin proteins and their active peptide segments is crucial for the development of detoxification agents and for discovering proteins with potential therapeutic applications. Existing methods for identifying and d...
ORGANISM(S): Ricinus communis 
2025-12-01 | PXD061213 | Pride
Unknown biological toxin protein Heuristic denovo protein sequencing Ricin toxin De novo sequencing Mass spectrometry 
UnknownTranslation and psychometric validation of the Escala de Impactos da Mucosite Oral em Pacientes Oncologicos (EIMOPO) in Chinese patients with cancer.
Not available
S-EPMC12677163 | biostudies-literature
ProteomicsSIRT7-induced PHF5A de-crotonylation regulates ageing progress through alternative splicing-mediated downregulation of CDK2
Dysregulation of protein post-translational modification (PTM) can lead to a variety of pathological process, such as abnormal sperm development, malignant tumorigenesis, depression, and ageing process. SIRT7 is a NAD + dependent protein deacetylase. Besides known deacetylation, SIRT7 may also have ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027232 | Pride
Human Crotonylation Fibroblasts 
ProteomicsA novel role for Teneurin C-terminal Associated Peptide (TCAP) in the regulation of cardiac activity in the Sydney rock oyster, Saccostrea glomerata
Teneurin C-terminal associated peptide (TCAP) is an ancient bioactive peptide that is highly conserved in metazoans. TCAP administration reduces cellular and behavioural stress in vertebrate and urochordate models, yet despite numerous studies in higher animals, there is limited knowledge of its rol...
ORGANISM(S): Saccostrea glomerata 
2023-01-27 | PXD039155 | Pride
Metabolism Transcriptome Teneurin Heart Tcap Heart rate Oysters Stress 
UnknownAn autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids.
Not available
S-EPMC8026396 | biostudies-literature
MetabolomicsOmics analysis in truffle (Tuber magnatum Pico): comparison of samples from different regions of Italy and from different seasons
Truffles are among the most expensive foods available in the market, usually used as flavoring additives for their distinctive aroma. The most valuable species is Tuber magnatum Pico, better known as 'Alba white truffle', in which bis(methylthio)methane is the key aroma compound. Given the high econ...
2020-12-10 | MTBLS808 | MetaboLights
GenomicsGenome-wide maps of Foxa2 binding sites in mouse embryonic stem cell-derived definitive endoderm cells
Foxa2 is required for endoderm differentiation into hepatic lineage. The mechanism of activation for Foxa2 during this developmental process has not been elucidated yet. We established an in vitro system to guide ES cells differentiating into definitive endoderm (DE) cells and the following DE cells...
ORGANISM(S): Mus musculus 
2012-08-29 | E-GEOD-40423 | biostudies-arrayexpress
MetabolomicsIntegrated gut metabolome and microbiome fingerprinting reveals that dysbiosis precedes allergic inflammation in IgE‐mediated pediatric cow's milk allergy

BACKGROUND: IgE-mediated cow's milk allergy (IgE-CMA) is one of the first allergies to arise in early childhood and may result from exposure to various milk allergens, of which β-lactoglobulin (BLG) and casein are the most important. Understanding the underlying mechanisms behin...

2024-02-15 | MTBLS6768 | MetaboLights
ProteomicsA proteomic investigation of sporophyte and gametophyte in the red seaweed Asparagopsis
The red seaweed, Asparagopsis taxiformis, is a promising ruminant feed-additive with significant anti-methanogenic properties, which could provide a global solution to climate-change. Emerging genomics in this species has provided a strong foundation for in-depth molecular investigations, including ...
ORGANISM(S): Asparagopsis taxiformis 
2023-01-26 | PXD035669 | Pride
Lc-ms/ms Sporophyte Proteomics Asparagopsis taxiformis (l6) Gametophyte 
UnknownComplex harmonic regularization with differential evolution in a memetic framework for biomarker selection.
Not available
S-EPMC6375558 | biostudies-literature
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