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The rapid emergence of drug resistant Staphylococcus aureus (S. aureus), in particular, methicillin-resistant S. aureus (MRSA) poses a serious threat to public health globally. Reuse of metal-based antimicrobials stands for one of the most promising strategies to resensitize drug resistant bacteria ...
ORGANISM(S): Staphylococcus aureus 
2021-09-10 | PXD025106 | Pride
A potential origin that appears to stay dormant in its native host Haloferax volcanii lacking the main active origins becomes activated and competent for replication of the entire chromosome when integrated into the chromosome of the origin-deleted H. mediterranei. Measurement of replication dynamic...
ORGANISM(S): Haloferax mediterranei 
By integrating fluorescence imaging with proteomic approach, we visualized Cr3+ protein targets mainly localized in mitochondria and identified eight Cr3+-binding proteins, including ATP synthase catalytic subunit beta (ATP5B).
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD027305 | Pride
Total RNA was extracted from 3-week-old WT and dja6 dja5 seedlings grown on MS medium. RNA sequencing libraries were constructed and subjected to sequencing using an Illumina Hiseq 2500 platform. After a quality control, the gene expression profiling analysis was performed based on the number of tag...
ORGANISM(S): Arabidopsis thaliana 
We have comprehensively explored the origin utilisation in Haloferax mediterranei. Here we report three active chromosomal origins by genome-wide replication profiling, and demonstrate that when these three origins are deleted, a dormant origin becomes activated. Genomic DNA was extracted from the H...
ORGANISM(S): Haloferax mediterranei 
The physiological role of the spliced form of X-box-binding protein 1 (XBP1s), a key transcription factor of the endoplasmic reticulum (ER) stress response, in adipose tissue remains largely unknown. Here we show that overexpression of XBP1s promotes adiponectin multimerization in adipocytes, thereb...
ORGANISM(S): Mus musculus 
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