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MetabolomicsDiscovery and validation of potential serum biomarkers for heart failure by untargeted metabolomics

Detection of biomarkers was extremely important for the early diagnosis, prognosis and therapy optimization of diseases. The purpose of this study was to investigate the differences in serum metabolites between patients with heart failure (HF) and healthy controls (HC), and to diagnose HF qualita...

2025-07-18 | MTBLS9586 | MetaboLights
GenomicsDynamically reorganized chromatin is the key for the reprogramming of somatic cells to pluripotent cells
We investigated genome-wide nucleosome coverage and histone methylation occupancies in somatic MEFs, intermediate pre-iPSCs and fully reprogrammed iPSCs. We found that nucleosome occupancies increased in promoter regions and decreased in intergenic regions in pre-iPSCs and then recover to an interme...
ORGANISM(S): Mus musculus 
2015-12-13 | E-GEOD-60627 | biostudies-arrayexpress
MetabolomicsComparative Metabolomic Profiling of Compatible and Incompatible Interactions Between Potato and Phytophthora infestans

Late blight is one of the main biological stresses limiting the potato yield; however, the biochemical mechanisms underlying the infection process of Phytophthora infestans remain unrevealed. In this study, the late blight-resistant potato cultivar Ziyun No.1 (R) and the susceptible cult...

2022-05-20 | MTBLS4365 | MetaboLights
ProteomicsThe inhibition effect of ERAP1-IN-1 on HepG2.2.15 cells
In our strudy, we preterated HepG2.2.15 cells with specific ERAP1 inhibitor ERAP1-IN-1(50μM). And then LC-MS/MS analysis was performed on a timsTOF Pro mass spectrometer.Finally we found that among the total peptides identified, ERAP1-IN-1-treated group had an reduction of the numbers of long pepti...
ORGANISM(S): Homo Sapiens 
2022-02-24 | PXD031858 |
ProteomicsProtein N-glycosylation aberrations and glycoproteomic network alterations in Osteoarthritis and Osteoarthritis with Type 2 diabetes
Whether the relationship between type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) could solely be attributed to the shared risk facts, like obesity, remains controversial. There have been a large number of studies that revealed the critical role of abnormal glycosylation in the pathogenesis o...
ORGANISM(S): Homo 
2021-09-26 | PXD028753 |
ProteomicsProteomics analysis reveals that the colicin I receptor CirA is involved in nutrient uptake by Aeromonas hydrophila
The colicin I receptor CirA is a well-studied outer membrane protein that has been reported to play important roles in antibiotic resistance, virulence, and iron homeostasis, although its exact physiological roles require further investigation.
ORGANISM(S): Aeromonas Hydrophila Subsp. Hydrophila Atcc 7966 
2022-10-28 | PXD037825 |
MetabolomicsGNPS - Proteomic and Metabolomic Characterization of COVID-19 Patient Sera MRMHR
Targeted mass spectrometric assays for the 22 proteins in a second test cohort containing 19 COVID-19 patients
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-05-30 | MSV000085515 | GNPS
MetabolomicsGNPS - Proteomic and Metabolomic Characterization of COVID-19 Patient Sera
Early detection and effective treatment of severe COVID-19 patients remain major challenges. Here, we performed proteomic and metabolomic profiling of sera from 46 COVID-19 and 53 control individuals. We then trained a machine learning model using proteomic and metabolomic measurements from a traini...
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 (ncbitaxon:2697049) Homo Sapiens (ncbitaxon:9606) 
2020-05-29 | MSV000085507 | GNPS
ProteomicsEdwardsiella tarda strain EIB 202 lysine acetylation and succinylation
The antibiotics resistance of Edwardsiella tarda is prevailing, seeking a novel antimicrobial strategies extremely urgent. Lysine acylation has been proved to play important role on the bacterial physiological function while its role on bacterial antibiotics resistance mechanism still largely unclea...
ORGANISM(S): Edwardsiella Tarda Eib202 
2022-05-12 | PXD033818 |
ProteomicsProteomic and Metabolomic Characterization of COVID-19 Patient Sera
Early detection and effective treatment of severe COVID-19 patients remain major challenges. Here, we performed proteomic and metabolomic profiling of sera from 46 COVID-19 and 53 control individuals. We then trained a machine learning model using proteomic and metabolomic measurements from a traini...
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 (ncbitaxon:2697049) Homo Sapiens (ncbitaxon:9606) 
2020-05-29 | MSV000085507 | MassIVE
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