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TranscriptomicsThe role of Gaq in MLL leukemogenesis
Beta-catenin has a central role for self-renewal of leukemic stem cells in Mixed Lineage Leukemia (MLL)-arranged acute myeloid leukemia (AML), however its upstream modulators that can enhance this pathway remain largely unexplored. Through genome-wide gene expression analysis, we identified a previo...
ORGANISM(S): Mus musculus 
2016-02-25 | E-MTAB-4078 | biostudies-arrayexpress
TranscriptomicsThe important role of GPR84 in MLL leukemogenesis
Beta-catenin signaling is required for establishment of leukemic stem cells (LSCs) in acute myeloid leukemia (AML), yet the upstream regulators that can augment this pathway are unknown. Through genome-wide gene expression analysis and functional studies, we identified an important role for GPR84 in...
ORGANISM(S): Mus musculus 
2014-10-15 | E-MTAB-1932 | biostudies-arrayexpress
ProteomicsTandem mass tag (TMT) quantitative proteomics of human acute myeloid leukaemia (AML)
The branched-chain amino acid (BCAA) pathway and high levels of BCAA transaminase 1 (BCAT1) have recently been associated with aggressiveness in several cancer entities. However, the mechanistic role of BCAT1 in this process remains largely uncertain. Here, by performing high-resolution proteomic an...
ORGANISM(S): Homo sapiens (Human) 
2020-02-21 | PXD008307 | Pride
Human Lc-msms Tmt Aml Leukemic stem cells 
ProteomicsHematopoietic Stem Cell (HSC) and Multipotent Progenitor (MPP1) quantitative proteomics
During adult bone marrow hematopoiesis, extremely rare and dormant hematopoietic stem cells (HSCs) harbor the highest self-renewal activity within all blood cells. They give rise to active HSCs, which generate multipotent progenitors (MPPs) which differentiate into lineage-committed progenitors and ...
ORGANISM(S): Mus musculus (Mouse) 
2014-08-21 | PXD000572 | Pride
Mouse Hsc Hematopoiesis 
UnknownAssociation between Obstructive Sleep Apnea and Cardiovascular Risk Factors: Variation by Age, Sex, and Race. The Multi-Ethnic Study of Atherosclerosis.
Not available
S-EPMC6322035 | biostudies-literature
MetabolomicsUntargeted metabolomics sheds light on the secondary metabolism of fungi triggered by choline-based ionic liquids
Fungal secondary metabolites constitute a rich source of yet undiscovered bioactive compounds. Their production is often silent under standard laboratory conditions, but the production of some compounds can be triggered simply by altering the cultivation conditions. The usage of an organic salt - io...
2022-07-15 | MTBLS5072 | MetaboLights
TranscriptomicsIntestinal myofibroblast vs skin fibroblast
Pericryptal myofibroblasts in the colon and rectum play an important role in regulating the normal colorectal stem cell niche and facilitating tumour progression. Myofibroblasts have previously mostly been distinguished from normal fibroblasts only by the expression of α smooth muscle actin (αSMA)...
ORGANISM(S): Homo sapiens 
2016-04-06 | E-GEOD-77474 | biostudies-arrayexpress
UnknownElevations in neutrophils with obstructive sleep apnea: The Multi-Ethnic Study of Atherosclerosis (MESA).
Not available
S-EPMC5842816 | biostudies-literature
UnknownA pathogenic in-frame deletion-insertion variant in BEST1 phenocopies Stargardt disease.
Not available
S-EPMC9746905 | biostudies-literature
UnknownNon-invasive detection and complementary diagnosis of liver metastases via chemokine receptor 4 imaging.
Not available
S-EPMC9363530 | biostudies-literature
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