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Antibiotic-resistant bacteria can escape from the killing of host immune and settle in the host to form persistent infections. In this study, we investigated the environmental adaptation mechanism of resistant Staphyloccus aureus (S. aureus) to host environment by Data-independent acquisition based ...
ORGANISM(S): Staphylococcus aureus 
2022-05-31 | PXD029584 | Pride
A novel approach combined nucleolar beacon with proximity labeling to obtain the nucleolar proteome. These techniques offer effective tools for investigating nucleolar functions in living cells and present a potential application method for drug delivery.
ORGANISM(S): Homo sapiens (Human) 
2025-06-23 | PXD059125 | Pride
The piRNA machinery is known for its role in mediating epigenetic silencing of transposons. Recent studies suggest that this function also involves piRNA-guided cleavage of transposon-derived transcripts. As many piRNAs also appear to have the capacity to target diverse mRNAs, this raises the intrig...
ORGANISM(S): Mus musculus 
These findings illuminate dual mechanisms driving CRAB pathogenicity-extensive drug resistance combined with heightened host inflammatory response-and suggest novel intervention strategies targeting OMVs-mediated immune modulation.
ORGANISM(S): Acinetobacter Baumannii A424 
2026-01-23 | PXD073433 |
To characterize the accessibility of α-syn to LPC and DOPS, we performed cross-linking experiments coupled with mass spectrometry (XL-MS). We mixed 15N-labeled and unlabeled Ac-α-syn at a 1:1 ratio and selected the cross-linked fragments containing both 15N-labeled and unlabeled Ac-α-syn to map the ...
ORGANISM(S): Homo Sapiens 
2024-12-26 | PXD059259 |
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