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ProteomicsDiscovering new peripheral plasma biomarkers to identify cognitive decline in type 2 diabetes
Type 2 diabetes mellitus (T2DM) is an independent risk factor of Alzheimer's disease (AD), thus, identifying who among the increasing T2DM populations may develop into AD is important for early intervention. By using TMT-labeling coupled high-throughput mass spectrometry, we conducted a comprehensiv...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD027870 | Pride
Type 2 diabetes Mild cognitive impairment Proteomics Cip2a Alzheimer's disease Diagnostic biomarkers 
ProteomicsTau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway
By precisely dissected MS for proteomics, we found that donepezil remarkably restored (at high dose), even elevated (at low dose) the level of vacuolar protein sorting-associated protein 37D (VP37D), an autophagy-related protein, in hTauMS mice.
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD023297 | Pride
Mouse Medial septum Hippocampus Alzheimer’s disease Cholinergic neuron Tau accumulation 
ProteomicsPlatelet biomarkers identifying mild cognitive impairment in type 2 diabetes patients
Here, we performed platelet proteomics in T2DM patients with MCI (T2DM-MCI) and without MCI (T2DM-nMCI)
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023316 | Pride
Alzheimer's disease  mild cognitive impairment  type 2 diabetes mellitus  peripheral biomarkers  platelet  proteomics  optineurin 
GenomicsGenome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)

This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cel...

phs000361.v1.p1 | EGA
ProteomicsPick-up single-cell proteomic analysis for quantifying up to 3000 proteins in a tumor cell
The shotgun proteomic analysis is currently the most promising single-cell protein sequencing technology, however its identification level of ~1000 proteins per cell is still insufficient for practical applications. Here, we develop a pick-up single-cell proteomic analysis (PiSPA) workflow to achiev...
ORGANISM(S): Homo Sapiens 
2023-10-30 | PXD041966 |
ProteomicsSimultaneous deep transcriptome and proteome profiling in single mouse oocytes
Deep proteome data in the single-cell multi-omics analysis of single mouse oocytes.
ORGANISM(S): Mus Musculus 
PXD043935 |
ProteomicsTargeting vulnerable microcircuit in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss
Background:Episodic memory loss is a prominent clinical manifestation of Alzheimer's disease(AD), which is closely related to tau pathology and hippocampal impairment. Given the heterogeneity of brain neurons, the precise role of different brain neurons in terms of their sensitivity to tau accumulat...
ORGANISM(S): Mus Musculus 
PXD043883 |
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