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UnknownAssociation of glycemic variability with short- and long-term mortality in critically ill patients with trauma.
The relationship between glycemic variability (GV) and mortality in critically ill trauma patients remains unclear. We evaluated whether GV, quantified by the coefficient of variation (CV) of glucose during the ICU stay, is associated with short- and long-term mortality in this population. Using the...
S-EPMC12820317 | biostudies-literature
UnknownAn Esterase-Responsive SLC7A11 shRNA Delivery System Induced Ferroptosis and Suppressed Hepatocellular Carcinoma Progression.
Ferroptosis has garnered attention as a potential approach to fight against cancer, which is characterized by the iron-driven buildup of lipid peroxidation. However, the robust defense mechanisms against intracellular ferroptosis pose significant challenges to its effective induction. In this paper,...
S-EPMC10891814 | biostudies-literature
UnknownHazardous Heavy Metals Accumulation and Health Risk Assessment of Different Vegetable Species in Contaminated Soils from a Typical Mining City, Central China.
Heavy metal poisoning has caused serious and widespread human tragedies via the food chain. To alleviate heavy metal pollution, particular attention should be paid to low accumulating vegetables and crops. In this study, the concentrations of five hazardous heavy metals (HMs), including copper (Cu),...
S-EPMC7967305 | biostudies-literature
UnknownEGR1 suppresses HCC growth and aerobic glycolysis by transcriptionally downregulating PFKL.

Background

Hepatocellular Carcinoma (HCC) is a matter of great global public health importance; however, its current therapeutic effectiveness is deemed inadequate, and the range of therapeutic targets is limited. The aim of this study was to identify early growth response 1 (EGR1) as a tran...
S-EPMC10823730 | biostudies-literature
MetabolomicsAlterations in the gut microbiota and metabolic profiles coincide with intestinal damage in mice with a bloodborne Candida albicans infection
Candida albicans is an opportunistic fungus that can threaten life especially in patients with candidemia. The morbidity and mortality of candidemia originating from a central venous catheter (CVC) and illicit intravenous drug use (IVDU) are increasing. However, the mechanism underlying the bloodbor...
2021-04-13 | MTBLS1918 | MetaboLights
UnknownAcute transverse myelitis and associate vaccine complication in SARS-CoV-2 patients: a retrospective cohort analysis in real-world database
Not available
S-EPMC12344938 | biostudies-literature
UnknownImpact of Variability in Portal Venous Phase Acquisition Timing in Tumor Density Measurement and Treatment Response Assessment: Metastatic Colorectal Cancer as a Paradigm.

Purpose

New response patterns to anticancer drugs have led tumor size-based response criteria to shift to also include density measurements. Choi criteria, for instance, categorize antiangiogenic therapy response as a decrease in tumor density > 15% at the portal venous phase (PVP). We studi...
S-EPMC6874047 | biostudies-literature
UnknownCorrelation analysis between the expression of serum microRNA-665 and the degree of coronary artery stenosis and major adverse cardiovascular events in patients with acute myocardial infarction.

Background

The purpose of this study was to explore the expression of miR-665 in acute myocardial infarction (AMI) and evaluate its significance in the diagnosis and prognosis of AMI.

Methods

100 patients with AMI were selected as the study group and 80 healthy subjects were chosen as...
S-EPMC11418203 | biostudies-literature
ProteomicsProteome profiling of colorectal cancer-infiltrating T cells to screen key regulators of CRC progression.
Using a tandem mass tag (TMT)-based quantitative proteomic study, we described the protein expression pattern of colorectal cancer-infiltrating T cells, revealed T cell dysfunctions in CRC, screened key regulator of CRC progression.
ORGANISM(S): Homo Sapiens 
2023-04-06 | PXD041366 |
ProteomicsTargeting NADPH oxidase and integrin α5β1 to inhibit neutrophil extracellular traps-mediated metastasis in colorectal cancer
Using multiple mass spectrometry-based proteomic approaches, our results comprehensively elucidate the entire process by which increased NETs accelerate tumor progression.
ORGANISM(S): Homo Sapiens 
PXD046490 |
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