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UnknownPhase II Trial and Correlative Genomic Analysis of Everolimus Plus Bevacizumab in Advanced Non-Clear Cell Renal Cell Carcinoma.
Not available
S-EPMC5791841 | biostudies-literature
UnknownNSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.
Not available
S-EPMC4688131 | biostudies-literature
ProteomicsRole of GATA-2 -77 enhancer in murine blood progenitor cells
We discovered enhancers that control GATA-2 expression during mouse development and in adult and generated mutant mouse strains that lack these enhancers, and these mice have very specific and important phenotypes that revealed GATA-2 mechanisms to control stem and progenitor cell transitions. In th...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-05 | PXD013855 | Pride
Deep analysis Primary tissue Targeted proteomics Label-free proteomics 
TranscriptomicsOncogenic SDH mutation underlies global epigenomic instability in gastrointestinal stromal tumor
We have discovered a striking connection between mitochondrial dysfunction and epigenomic instability, manifested by global biallelic DNA cytosine 5-methylation and loss of 5-hydroxymethycytosine within succinate dehydrogenase (SDH)-null gastrointestinal stromal tumors (GIST) relative to those beari...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-34387 | biostudies-arrayexpress
TranscriptomicsA functional genomics predictive network model identifies regulators of inflammatory bowel disease: Microarray Analysis of Human Blood and Intestinal Biopsy Samples from a Phase 2b, Double-blind, Placebo-controlled Study of Ustekinumab in Crohn's Disease
Microarray Analysis of Human Whole Blood and Intestinal Biopsy Samples from a Phase 2b, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study of Ustekinumab in Crohn’s Disease 329 Crohn's biopsies from multiple regions in the intestine of 87 anti TNFa refractory patients an...
ORGANISM(S): Homo sapiens 
2017-07-07 | E-GEOD-100833 | biostudies-arrayexpress
ProteomicsTargeted mass spectrometry enables multiplexed quantification of immunomodulatory proteins in clinical biospecimens
Immunotherapies are revolutionizing cancer care, producing durable responses and potentially cures in a subset of patients. However, response rates are low for most tumors, grade 3/4 toxicities are not uncommon, and our current understanding of tumor immunobiology is incomplete. While hundreds of im...
ORGANISM(S): Homo Sapiens 
2022-02-28 | PXD029167 | panorama
ProteomicsProteogenomic analysis of chemo-refractory high grade serous ovarian cancer
To improve our understanding of the molecular basis of chemo-refractory high grade serous ovarian cancers (HGSOCs), we characterized the proteogenomic landscape of 242 (refractory and sensitive) HGSOCs, representing one discovery and two independent validation cohorts (spanning four academic centers...
ORGANISM(S): Homo Sapiens 
PXD040742 | panorama
UnknownRisk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: a multicenter international myeloma working group study.
Not available
S-EPMC4109061 | biostudies-literature
MetabolomicsGNPS - GNPS Paper Novel Stenothricin Analog Supporting Information.
Mass spectrometry data, NMR, and sequencing data in support of the discovery of stenothricin-GNPS. Secondary metabolite production of Streptomyces Roseosporus was compared against Streptomyces DSM5940.
ORGANISM(S): Streptomyces (ncbitaxon:1883) 
2015-07-30 | MSV000079204 | GNPS
UnknownNiraparib in patients with metastatic castration-resistant prostate cancer and DNA repair gene defects (GALAHAD): a multicentre, open-label, phase 2 trial.
Not available
S-EPMC9361481 | biostudies-literature
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