Sort   by:  
 Page size 
ProteomicsSpatially-Resolved Proteomic Analysis of the Lens Extracellular Diffusion Barrier
This study is to characterize the molecular components that could contribute to the formation of lens extracellular diffusion barrier. Three regions were isolated from lens cortex using laser capture microdissection and the proteome changes in these three regions were studied.
ORGANISM(S): Bos taurus (Bovine) 
2022-02-17 | PXD025337 | Pride
Extracellular diffusion barrier Lens fiber cells Quantitative mass spectrometry Laser capture microdissection 
TranscriptomicsChIP-chip of siGFP- or siHOTTIP-treated foreskin fibroblasts with anti-H3K4me3, anti-H3K27me3, anti-H3K4me2, anti-histone, anti-MLL1, and anti-WDR5 antibodies on HOX tiling array
Coordinate loss of MLL1 and WDR5 occupancy caused by HOTTIP knockdown were observed in distal HOXA genes. These regions correspondingly lost H3K4me3 and H3K4me2, without changes in pan-histone or H3K27me3. human foreskin fibroblasts (CRL2091), anti-H3K4me3 (Abcam ab8580, lot#1016899), anti-H3K4me2 (...
ORGANISM(S): Homo sapiens 
2011-03-21 | E-GEOD-26540 | biostudies-arrayexpress
MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
TranscriptomicsTranscription profiling of mouse skins of embryos lacking Grainyhead-like epithelial transactivator (Get-1)
Defective permeability barrier is an important feature of many skin diseases and causes mortality in premature infants. To investigate the control of barrier formation, we characterized the epidermally expressed Grainyhead-like epithelial transactivator (Get-1)/Grhl3, a conserved mammalian homologue...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-7381 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of murine livers after resveratrol treatment of mice on a high-calorie diet
Resveratrol (3,5,4'-trihydroxystilbene) extends the lifespan of diverse species including yeast, worms, and flies. In these organisms, lifespan extension is dependent on Sir2, a conserved deacetylase proposed to underlie the beneficial effects of caloric restriction (CR). Here we show that resveratr...
ORGANISM(S): Mus musculus 
2008-06-21 | E-GEOD-6089 | biostudies-arrayexpress
TranscriptomicsValidation data for Lawrence Livermore Microbial Detection Arrays
This SuperSeries is composed of the following subset Series: GSE24626: Validation data for Lawrence Livermore Microbial Detection Array version 2 GSE24699: Validation data for Lawrence Livermore Microbial Detection Array version 1 Refer to individual Series
ORGANISM(S): Bovine viral diarrhea virus 1 
2010-10-15 | E-GEOD-24700 | biostudies-arrayexpress
TranscriptomicsValidation data for Lawrence Livermore Microbial Detection Array version 2
We designed a pan-Microbial Detection Array (MDA) to detect all known viruses (including phage), bacteria, and plasmids. Family-specific probes were selected for all sequenced viral and bacterial complete genomes, segments, and plasmids. Probes were designed to tolerate some sequence variation to en...
ORGANISM(S): Bovine viral diarrhea virus 1 
2010-10-15 | E-GEOD-24626 | biostudies-arrayexpress
TranscriptomicsValidation data for Lawrence Livermore Microbial Detection Array version 1
We designed a pan-Microbial Detection Array (MDA) to detect all known viruses (including phage), bacteria, and plasmids. Family-specific probes were selected for all sequenced viral and bacterial complete genomes, segments, and plasmids. Probes were designed to tolerate some sequence variation to en...
ORGANISM(S): Vaccinia virus Lister 
2010-10-15 | E-GEOD-24699 | biostudies-arrayexpress
TranscriptomicsSelective demethylation and altered gene expression are associated with ICF Syndrome in human induced pluripotent stem cells and mesenchymal stem cells
Immunodeficiency, Centromeric Instability, and Facial Anomalies Type I (ICF1) Syndrome is a rare genetic disease caused by mutations in DNMT3B, a de novo DNA methyltransferase. However, the molecular basis of how DNMT3B-deficiency leads to ICF1 pathogenesis is unclear. Induced pluripotent stem cell ...
ORGANISM(S): Homo sapiens 
2014-11-17 | E-GEOD-46030 | biostudies-arrayexpress
TranscriptomicsMultiple oxygen tension environments reveal diverse patterns of transcriptional regulation in primary astrocytes
The central nervous system normally functions at O2 levels which would be regarded as hypoxic by most other tissues. However, most in vitro studies of neurons and astrocytes are conducted under hyperoxic conditions without consideration of O2-dependent cellular adaptation. We analyzed the reactivi...
ORGANISM(S): Rattus norvegicus 
2012-09-20 | E-GEOD-29296 | biostudies-arrayexpress
Sort   by:  
 Page size