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TranscriptomicsChemical modifications mark alternatively spliced and actively degrading messenger RNAs in Arabidopsis and humans
Post-transcriptional chemical modification of RNA bases is a widespread and physiologically relevant regulator of RNA maturation, stability, and function. While modifications are best characterized in short, noncoding RNAs such as transfer RNAs (tRNAs), growing evidence indicates that messenger RNAs...
ORGANISM(S): Homo sapiens 
2015-10-31 | E-GEOD-66224 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse CD8 T cells from two mouse strains (OTI-WT and OTI-TRAF6 knockout) at two timepoints
CD8 T cells play a crucial role in immunity to infection and cancer. They are maintained in constant numbers, but upon stimulation with antigen undergo a developmental program characterized by distinct phases encompassing the expansion and then contraction of antigen-specific populations, followed ...
ORGANISM(S): Mus musculus 
2009-06-24 | E-GEOD-15750 | biostudies-arrayexpress
TranscriptomicsAltered gene expression in Werner & Bloom syndromes is associated with sequences having G-quadruplex forming potential
The human Werner and Bloom syndromes (WS and BS) are caused by deficiencies in the WRN and BLM RecQ helicases, respectively. WRN, BLM and their S. cerevisiae homologue Sgs1, are particularly active in vitro in unwinding G-quadruplex DNA (G4-DNA), a family of non-canonical nucleic acid structures fo...
ORGANISM(S): Homo sapiens 
2009-12-09 | E-GEOD-19205 | biostudies-arrayexpress
TranscriptomicsGenome-wide double-stranded RNA sequencing reveals the functional significance of base-paired RNAs in Arabidopsis
The functional structure of all biologically active molecules is dependent on intra- and inter-molecular interactions. This is especially evident for RNA molecules whose functionality, maturation, and regulation requires formation of correct secondary structure through encoded base-pairing interacti...
ORGANISM(S): Arabidopsis thaliana 
2010-10-04 | E-GEOD-23439 | biostudies-arrayexpress
UnknownThe furosemide stress test for prediction of worsening acute kidney injury in critically ill patients: A multicenter, prospective, observational study.
Not available
S-EPMC8704439 | biostudies-literature
UnknownOn the remarkable resistance to oxidation by the Bi<sub>18</sub><sup>-</sup> cluster.
Not available
S-EPMC11524183 | biostudies-literature
UnknownModulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase I pilot study.
Not available
S-EPMC3076314 | biostudies-literature
UnknownA new class of α-ketoamide derivatives with potent anticancer and anti-SARS-CoV-2 activities.
Not available
S-EPMC7873610 | biostudies-literature
GenomicsCIDR: Collaborative Study on the Genetics of Alcoholism Case Control Study

This is a case-control study of alcoholism, in which the subjects have been drawn from the Collaborative Study on the Genetics of Alcoholism (COGA), a large, ongoing family-based study that includes subjects from seven sites around the US. COGA has gathered detailed, standardized data on ...

phs000125.v1.p1 | EGA
UnknownExome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease.
Not available
S-EPMC5899829 | biostudies-literature
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