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ProteomicsDrosha/Dicer/miR-7/TGF-β2 axis Sustained Acidic Microenvironment-induced Lung Metastasis
Extracellular pH (pHe) is lower in many tumors than in the corresponding normal tissue. Acidic tumor microenvironment has been shown to facilitate epithelial mesenchymal transition (EMT) and tumor metastasis, while the mechanisms underlying tumor acidic microenvironment-induced tumor cell metastasis...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD016524 | Pride
Tumor acidic microenvironment  epithelial-mesenchymal transition  metastasis  microrna-7  tgf-β2 
ProteomicsQuantification of protein level changes under elevated mitochondrial abasic site damage
The project aims to examine the protein level changes under induced mitochondrial abasic site lesions in HeLa cells using stable isotope labeling by amino acids in cell culture (SILAC)-based quantitative proteomics. The data revealed significant changes in the expression level of several proteins. ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-03 | PXD063576 | Pride
Mitochondrial dna damage Mitochondrial dna repair Abasic sites Mitochondrial dna degradation 
ProteomicsThe lysine acetylome in Vibrio mimicus
In the present study, we performed the first global lysine acetylome in V. mimicus through a combination of highly sensitive immune-affinity purification and high-resolution LC−MS/MS, and identified 1097 lysine-acetylated sites on 582 proteins. Of the acetylated proteins, more than half were acetyla...
ORGANISM(S): Vibrio Mimicus Vm603 
2021-09-14 | PXD028467 |
UnknownActivation of GATA binding protein 6 (GATA6) sustains oncogenic lineage-survival in esophageal adenocarcinoma.
Not available
S-EPMC3306720 | biostudies-literature
ProteomicsProteomics analysis of insulin sensitive tissues in high fat diet fed mice
The popularity of high fat foods in modern society has been associated with epidemic of various metabolic diseases characterized by insulin resistance, the pathology of which involves complex interactions between multiple tissues such as liver, skeletal muscle and white adipose tissue (WAT). To unco...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-26 | PXD021046 | Pride
Insulin resistance  high fat diet  multi-tissue analysis 
UnknownThe role of metabolic memory in diabetic kidney disease: identification of key genes and therapeutic targets.
Not available
S-EPMC11292736 | biostudies-literature
ProteomicsProteomics analysis of white adipose tissue in high fat diet fed mice
The popularity of high fat foods in modern society has been associated with epidemic of various metabolic diseases characterized by insulin resistance, the pathology of which involves complex interactions between multiple tissues such as liver, skeletal muscle and white adipose tissue (WAT). To unco...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD021019 | Pride
Insulin resistance  high fat diet  multi-tissue analysis 
ProteomicsQuantitative proteomic analysis of oxaliplatin induced peripheral neurotoxicity
We performed a data independent acquisition (DIA) -based quantitative proteomics strategy to investigate the global proteome alteration in the dorsal root ganglion (DRG) tissues from mice injected with oxaliplatin for different periods.
ORGANISM(S): Mus musculus (Mouse) 
2022-07-11 | PXD031322 | Pride
Metabolism Peripheral neurotoxicity Oxaliplatin Ros Quantitative proteomics 
TranscriptomicsTranscriptome sequencing of Pacific oyster Crassostrea gigas
Deep sequencing of mRNA from Pacific oyster Crassostrea gigas Competent larvae of Crassostrea gigas were treated with epinephrine solution, and then sampled at different time intervals. For shell damage experiment, shell were broken and then tissues were sampled at different time intervals.
ORGANISM(S): Crassostrea gigas 
2014-07-26 | E-GEOD-31011 | biostudies-arrayexpress
TranscriptomicsDifferences in gene expression and cytokines levels between newly diagnosed and chronic pediatric immune thrombocytopenia (ITP)
Immune thrombocytopenia (ITP) is an autoimmune disease where platelets are destroyed prematurely. In the majority of children the disease resolves but in some it becomes chronic. To investigate whether the two forms of the disease are similar or separate entities we performed DNA microarray analysis...
ORGANISM(S): Homo sapiens 
2013-08-05 | E-GEOD-46922 | biostudies-arrayexpress
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