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Metabolic dysfunction-associated fatty liver disease (MAFLD) has a global prevalence of about 25% and no approved therapy. Using metabolomic and proteomic analyses, we identified high expression of hepatic transketolase (TKT), a metabolic enzyme of the pentose phosphate pathway, in human and mouse M...
ORGANISM(S): Homo Sapiens 
2024-02-26 | PXD050130 |
Mouse glioma cells are recorded through patch-seq first, and the cytosol was collected afterwards, and the whole transcriptomic RNA library was reconstructed and sequenced afterwards.
ORGANISM(S): Mus musculus 
Embryonic stem cells (ESCs) were labeled with heavy isotopes, 13C615N4-arginine (Arg10) and 13C614N2-lysine (Lys6), or light isotopes, 12C614N4-arginine (Arg0) and 12C614N2-lysine (Lys0), respectively, for a total of 7 passages to ensure efficient labeling (>97%). The ESCs labeled with heavy isotope...
ORGANISM(S): Mus Musculus 
Diabetes retinopathy (DR) and diabetes kidney disease (DKD) are the complications of diabetes and causing serious health and economic burden to society. However, identification and characterization of early biomarkers for DKD, especially for non-proliferative DR (NPDR) patients with DKD, are still l...
ORGANISM(S): Homo Sapiens 
2022-08-19 | PXD036172 |
SUG1 associates with multiple transcription factors, such as OsBZR1, OsMADS56 and OsSPL13, to control grain size through GA and BR signaling as well as growth pathways.
ORGANISM(S): Oryza Sativa Japonica Group 
The production of secondary metabolites is one of the major mechanisms for beneficial rhizobacteria to antagonize plant pathogens. However, simultaneously producing large quantities of different secondary metabolites can pose great metabolic burdens and exerts a significant fitness cost on the produ...
ORGANISM(S): Pseudomonas Fluorescens F113 
In this research, to discover the interactions of mpox-A5 with host proteins, HEK293T cells were utilized and transfected with pCAGGS-HA-A5L plasmid (or pCAGGS-HA plasmid), harvested at 24h, Heterologous expression of MPXV A5L in HEK293T cells was performed for Co-IP with anti-HA beads, and Immunobl...
ORGANISM(S): Homo Sapiens 
2024-11-13 | PXD057872 |
To investigate the potentail anti-PD-L1 resistance mechanism in HCC, we examine the different proteins between hepa1-6 and res1-6 tumor cells. Proteins were digested with trypsin and following by high-resolution liquidchromatography-tandem MS(LC-MS/MS) analysis
ORGANISM(S): Mus Musculus 
2023-12-21 | PXD048069 |
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