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TranscriptomicsDirect reprogramming of human fibroblasts to functional hepatocyte-like cells
Plasticity of differentiated cells has been proved by nuclear transfer, induced pluripotent cells and transdifferentiation. Here we show that by transduction of 3 factors (FOXA3, HNF1A and HNF4A), human fetal fibroblasts can be converted to hepatocyte-like cells (hiHep cells), expressing hepatic mar...
ORGANISM(S): Homo sapiens 
2014-03-06 | E-GEOD-42643 | biostudies-arrayexpress
ProteomicsLymphatic platelet thrombosis limits bone repair by precluding lymphatic transporting DAMPs
In the musculoskeletal system, lymphatic vessels (LVs), which are interdigitated with blood vessels, travel and form an extensive transport network. Blood vessels in bone regulate osteogenesis and hematopoiesis, however, whether LVs in bone affect fracture healing is unclear. Here, we investigated t...
ORGANISM(S): Rattus Norvegicus 
PXD056584 |
ProteomicscTAGE5/MEA6 regulates LBR transport to maintain nuclear envelope integrity and safeguard against aging
IP-MS of fused MEA6-GFP and the control sample were performed. For MS analyses, peptides were resuspended in 0.1% FA and analyzed by LTQ Orbitrap Elite mass spectrometer (ThermoFisher Scientific) coupled online to an Easy-nLC 1000 (Thermo Fisher Scientific) in the data-dependent mode.
ORGANISM(S): Homo Sapiens 
PXD063263 |
ProteomicsPhosphoproteome and proteome of mouse hepatocyte maturation and human hepatic reprogramming
To identify central protein kinases that potentially promote the maturation, we chemically induced liver progenitor cells (CLiPs) from mouse hepatocytes using a previously established protocol, and profiled the phosphoproteome and proteome of freshly isolated primary mouse hepatocytes (MHs) and ALBU...
ORGANISM(S): Homo Sapiens Mus Musculus 
2022-08-05 | PXD035829 |
ProteomicsDeacetylation of Septin4 by NAD-dependent deacetylase SIRT2 mitigates damaging effects of hypertensive nephropathy
RATIONALE: Hypertension can lead to podocyte damage and subsequent apoptosis, eventually resulting in glomerulosclerosis. Although alleviating podocyte apoptosis has clinical significance for the treatment of hypertensive nephropathy, an effective therapeutic target has not yet been identified. The ...
ORGANISM(S): Mus Musculus 
2022-12-05 | PXD038538 |
UnknownMortality and Morbidity in Adults With Rheumatic Heart Disease.
Not available
S-EPMC11154374 | biostudies-literature
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