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ProteomicsSynergistic Therapeutic Effects of D-Mannitol-Cerium-Quercetin (Rutin) Coordination Polymer Nanoparticles on Acute Lung Injury
In our latest study, we pioneered the use of D-Mannitol-Cerium-Quercetin/Rutin coordination polymer nanoparticles (MCQ/R NPs) as a potential remedy for ALI. our in vivo studies with LPS-induced ALI mice showed significant mitigation of lung tissue inflammation. This groundbreaking research presents ...
ORGANISM(S): Mus Musculus 
2024-04-10 | PXD051350 |
ProteomicsTarget identification of dioxygenated amide derivatives interacting proteins
To identify the direct binding proteins of dioxygenated amide by chemical proteomics, we firstly evaluated the efficiency of optimized probe 6D-PP probe labelling the E. coli bacterial proteomes by in-gel fluorescence. Briefly, the E. coli bacterial lysates were incubated with 100 M probe 6D-PP und...
ORGANISM(S): Homo Sapiens 
2023-12-08 | PXD047691 |
TranscriptomicsGene expression differences between the pancreatic tissues of Pdx1-Cre;KrasLSL-G12D and Pdx1-Cre;KrasLSL-G12D;IKK2/betaF/F mice
Constitutive Kras and NF-kappaB activation is identified as signature alterations in human pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms of constitutive NF-kappaB activation in KrasG12D-induced PDAC are not yet understood. Here, we report that pancreas-targeted IKK2/beta inactivat...
ORGANISM(S): Mus musculus 
2012-01-24 | E-GEOD-27478 | biostudies-arrayexpress
UnknownCETN3 Deficiency Induces Microcephaly by Disrupting NPC Cell Fate through Impaired Centrosome Assembly and RNA Splicing
Not available
S-SCDT-10_1038-S44321-025-00302-7 | biostudies-other
TranscriptomicsTranscriptional profiling of pancreatic beta cells during maturation and with function-inactivating mutations
Islet β-cells from newborn mammals need a maturation process to become mature functional beta cells. The detailed molecular mechanisms were not completely understood. This study was designed to reveal the dynamic gene expression changes during pancreatic beta-cell maturation in postnatal mice. We al...
ORGANISM(S): Mus musculus 
2018-04-01 | E-MTAB-6615 | biostudies-arrayexpress
ProteomicsProteome of Mpox virus A5L-expressing HEK293T cells
In this research, to discover the interactions of mpox-A5 with host proteins, HEK293T cells were utilized and transfected with pCAGGS-HA-A5L plasmid (or pCAGGS-HA plasmid), harvested at 24h, Heterologous expression of MPXV A5L in HEK293T cells was performed for Co-IP with anti-HA beads, and Immunobl...
ORGANISM(S): Homo Sapiens 
2024-11-13 | PXD057872 |
TranscriptomicsRegulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling
Illumina Beadchip array analyses of mouse embryonic stem cell gene expression profiles in the presence of or upon knockdown of Aurka. An ES complementation 'rescue' system was employed to measure the effects of knockdown (minus Dox). Aurka was rescued to wildtype levels in the presence of Dox (plus ...
ORGANISM(S): Mus musculus 
2012-05-29 | E-GEOD-23541 | biostudies-arrayexpress
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