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TranscriptomicsTranscription profiling of human soluble guanylate cyclase-deficient U937 cells exposed to the nitric oxide (NO) donor S-nitrosoglutathione to provide insight into the cGMP-independent effects of NO
NO effects on gene expression, independent of cGMP, were examined globally. Differentiated human U937 cells that lack soluble guanylate cyclase were exposed to Snitrosoglutathione, a NO donor, or glutathione without or with dibutyryl-cAMP (Bt2cAMP). NO regulated 110 transcripts that annotated dispro...
ORGANISM(S): Homo sapiens 
2007-09-11 | E-GEOD-2649 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of THP-1 cells reveals nitric oxide activation of Erk regulates the stability and translation of mRNA transcripts containing CU-rich elements
Nitric oxide (NO) can stabilize mRNA by activating p38 mitogen-activated protein kinase (MAPK). Here, transcript stabilization by NO was investigated in human THP-1 cells using microarrays. After LPS pre-stimulation, cells were treated with actinomycin D and then exposed to NO without or with the p3...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-4228 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of asthma induced mice treated with LPS in a controlled environment
Examination of gene expression associated with asthma induced by treatment of mice with LPS in a controlled environment. Related experiment E-TIGR-8
ORGANISM(S): Mus musculus 
2005-01-01 | E-TIGR-7 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse strains responsive/unresponsive to asbestos backcrossed to either C57B or 129
Asbestos disease model: Occupational lung disease comprises a wide variety of disorders caused by the inhalation or ingestion of dust particles or noxious chemical. These disorders include pneumoconiosis, asbestos-related pleural and others. Although asbestos is carcinogenic to humans, the mech...
ORGANISM(S): Mus musculus 
2007-02-14 | E-TIGR-10 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of asthma induced mice treated with LPS in a controlled environment
Examination of gene expression associated with asthma induced by treatment of mice with LPS in a controlled environment, realted experiment E-TIGR-7.
ORGANISM(S): Mus musculus 
2005-01-01 | E-TIGR-8 | biostudies-arrayexpress
TranscriptomicsKidney development time course
Array Design; Mouse Compugen 22K Spotted Oligo Author; Sean Grimmond Common Reference (Yes/No, ID); Yes Mouse universal Reference (Stratagene) Concentration; 100 Data processing/normalization; Lowess Normalisation GeneSpring) Developmental Stage; embryonic Diseased/Normal; normal Dye Swap; red/green...
ORGANISM(S): Mus musculus 
2010-06-09 | E-GEOD-2282 | biostudies-arrayexpress
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