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MetabolomicsGut microbiome dysbiosis drives metabolic dysfunction in Familial dysautonomia
Familial dysautonomia (FD) is a rare genetic neurologic disorder caused by impaired neuronal development and progressive degeneration of both the peripheral and central nervous systems. FD is monogenic, with >99.4% of patients sharing an identical point mutation in the elongator acetyltransferase co...
2022-12-06 | MTBLS5138 | MetaboLights
TranscriptomicsTranscription profiling of FACS sorted mouse calvarial osteroblasts at defined differentiation stages to identify genes highly associated with osteoblast differentiation
This study compares a comprehensive microarray analysis of unsorted mCOB cultures at two level of cell differentiation with cells that are more homogeneous for a level of cellular differentiation. It demonstrates the loss of information and in some cases misinformation that occurs when a heterogeneo...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2332 | biostudies-arrayexpress
UnknownA Transcriptionally Definable Subgroup of Triple-Negative Breast and Ovarian Cancer Samples Shows Sensitivity to HSP90 Inhibition.
Not available
S-EPMC6942625 | biostudies-literature
UnknownDistinct and convergent effects of <i>SF3B1</i> mutations in human breast cancer.
Not available
S-EPMC12541443 | biostudies-literature
Genomicsena-DATASET-dkfz_b062-21-02-2018-14:40:33:479-591 - samples
This dataset contains whole exome sequencing data from 24 patients. The Agilent SureSelect Human All Exon 50-Mb target enrichment kit was used to capture all human exons for deep sequencing. For each patient a tumour and control sample has been sequenced on a Illumina HiSeq2000 instrument in paired-...
EGAD00001003973 | EGA
UnknownGut microbiota density influences host physiology and is shaped by host and microbial factors.
Not available
S-EPMC6342524 | biostudies-literature
TranscriptomicsDiscovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukemia by whole genome sequencing
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole genome sequencing of tumour and normal DNA from 12 children with ETP ALL and assessed the frequency of somatic alterations in 52 ETP and 42 non-ETP T-ALL samples by...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-28703 | biostudies-arrayexpress
ProteomicsDesign, Implementation and Multisite Evaluation of a System Suitability Protocol for the Quantitative Assessment of Instrument Performance in Liquid Chromatography-Multiple Reaction Monitoring-MS (LC-MRM-MS)
Multiple reaction monitoring (MRM) mass spectrometry coupled with stable isotope dilution (SID) and liquid chromatography (LC) is increasingly used in biological and clinical studies for precise and reproducible quantification of peptides and proteins in complex sample matrices. Robust LC-SID-MRM-MS...
ORGANISM(S): Bos Taurus 
PXD010535 | panorama
Genomicsena-DATASET-dkfz_b062-23-02-2018-16:41:10:412-192 - samples
This dataset contains ChIP sequencing data from 24 patients. ChIP of 5–10 mg flash-frozen primary ependymoma tumour was performed using 5 mg H3K27ac antibody per ChIP experiment. The enriched DNA has been sequenced on a Illumina HiSeq2000 instrument in paired-end mode. Up to two lanes per sampl...
EGAD00001003979 | EGA
Genomicsena-DATASET-dkfz_b062-16-02-2018-17:18:40:151-347 - samples
This dataset conatains RNA sequencing data from 24 patients. Up to two lanes per tumour sample have been seqeunced on a Illumina HiSeq2000 instrument in paired-end mode resulting in 58 Fastq files.
EGAD00001003966 | EGA
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