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GenomicsGenome wide maps of E2F7 binding in IMR90 cells
Oncogene-induced senescence is an anti-proliferative stress response program that acts as a fail-safe mechanism to limit oncogenic transformation and is regulated by the retinoblastoma protein (RB) and p53 tumor suppressor pathways. We identify the atypical E2F family member E2F7 as the only E2F t...
ORGANISM(S): Homo sapiens 
2012-08-25 | E-GEOD-40343 | biostudies-arrayexpress
TranscriptomicsExpression data from either growing IMR90 human fibroblasts or senescent IMR90 cells with Ras expression and indicated hairpins
Oncogene-induced senescence is an anti-proliferative stress response program that acts as a fail-safe mechanism to limit oncogenic transformation and is regulated by the retinoblastoma protein (RB) and p53 tumor suppressor pathways. We identify the atypical E2F family member E2F7 as the only E2F t...
ORGANISM(S): Homo sapiens 
2012-08-25 | E-GEOD-40349 | biostudies-arrayexpress
ProteomicsProteomic profiles of control, AUF1-overexpressed, and CVB3-infected HeLa cells
CVB 3C protease (3Cpro) plays a specific cleavage role on AU-rich binding factor (AUF1, also called as hnRNP D), consequently disputes the regulations of AUF1 on downstream molecules stabilities and transcriptions. In our work, iTRAQ approach was firstly used to quantitatively identify differentiall...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD021094 | Pride
Lc-ms Lysate Human hela cells Auf1 
MetabolomicsMicrobiome and metabolome features in inflammatory bowel disease via multi-omics integration analyses across cohorts

The perturbations of the gut microbiota and metabolites are closely associated with the progression of inflammatory bowel disease (IBD). However, inconsistent findings across studies impede a comprehensive understanding of their roles in IBD and their potential as reliable diagnostic biomarkers. ...

2026-01-28 | MTBLS8713 | MetaboLights
GenomicsGenome wide maps of p53 binding in IMR90 cells
Oncogene-induced senescence is an anti-proliferative stress response program that acts as a fail-safe mechanism to limit oncogenic transformation and is regulated by the retinoblastoma protein (RB) and p53 tumor suppressor pathways. We identify the atypical E2F family member E2F7 as the only E2F t...
ORGANISM(S): Homo sapiens 
2012-12-05 | E-GEOD-42728 | biostudies-arrayexpress
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