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To create a dataset of PSMs that does not exhibit tryptic bias, we selected PSMs with a uniform distribution of amino acids at the C-terminal peptide positions from two datasets: MassIVE-KB [Wang2018] and PROSPECT [Shouman2022]. The MassIVE-KB dataset contains 30 million PSMs and consists entirely o...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-02-05 | MSV000094014 | MassIVE
Heterosis is a fundamental biological phenomenon characterized by the superior performance of a hybrid over its parents in many traits, but the underlying molecular basis remains elusive. To investigate whether DNA methylation plays a role in heterosis, we compared at single base-pair resolution th...
ORGANISM(S): Arabidopsis thaliana 
This study reports on the design of a library of photoprobes based on the potent spider toxin Huwentoxin-IV and the determination of the toxin binding interface on VSD2 of Nav1.7 through a photocrosslinking and tandem mass spectrometry approach. Our Huwentoxin-IV probes selectively crosslink to extr...
ORGANISM(S): Homo sapiens (Human) 
2019-11-18 | PXD015037 | Pride
The Antarctic green alga Chlamydomonas sp. UWO241 (UWO241) survives in the deep photoc zone of the permanently ice-covered Lake Bonney in the McMurdo Dry Valleys. The extreme habitat in its natural environment has given way to unique adaptive mechanisms in this halotolerant psychrophile. One of the ...
ORGANISM(S): Chlamydomonas Sp. Uwo 241 
Mouse Embryonic Stem (ES) cells express a unique set of microRNAs (miRNAs), the miR-290-295 cluster. To elucidate the role of these miRNAs and how they integrate into the ES cell regulatory network requires identification of their direct regulatory targets. The difficulty, however, arises from the l...
ORGANISM(S): Mus musculus 
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