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ProteomicsDevelopment of Photocrosslinking Probes Based on Huwentoxin-IV to Map the Site of Interaction on Nav1.7
This study reports on the design of a library of photoprobes based on the potent spider toxin Huwentoxin-IV and the determination of the toxin binding interface on VSD2 of Nav1.7 through a photocrosslinking and tandem mass spectrometry approach. Our Huwentoxin-IV probes selectively crosslink to extr...
ORGANISM(S): Homo sapiens (Human) 
2019-11-18 | PXD015037 | Pride
Nav1.7 Photoaffinity labelling Huwentoxin-iv Diazirine Peptide mapping 
UnknownDevelopment of Photocrosslinking Probes Based on Huwentoxin-IV to Map the Site of Interaction on Nav1.7.
Not available
S-EPMC7083225 | biostudies-literature
UnknownRecombinant expression and in vitro characterisation of active Huwentoxin-IV.
Not available
S-EPMC3855799 | biostudies-literature
UnknownComprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNav1.7.
Not available
S-EPMC6996889 | biostudies-literature
UnknownAnalysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin huwentoxin-IV (μ-TRTX-Hh2a).
Not available
S-EPMC3829356 | biostudies-literature
UnknownCommon molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV.
Not available
S-EPMC3149324 | biostudies-literature
UnknownThe structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.
Not available
S-EPMC5354290 | biostudies-literature
UnknownNative pyroglutamation of huwentoxin-IV: a post-translational modification that increases the trapping ability to the sodium channel.
Not available
S-EPMC3691182 | biostudies-literature
UnknownThe venom of <i>Cyriopagopus schmidti</i> spider contains a natural huwentoxin-IV analogue with unexpected improved analgesic potential.
Not available
S-EPMC12019880 | biostudies-literature
UnknownThe tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation.
Not available
S-EPMC2993464 | biostudies-literature
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