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MetabolomicsOsh2 mediates Candida resistance to miltefosine by regulating zymosterol transport
Miltefosine has been identified for its antifungal properties, yet the mechanisms underlying its action and the development of resistance remain unclear. In this study, we induced drug resistance in various Candida species through concentration gradient exposure, successfully obtaining a miltefosine...
2025-07-03 | MTBLS12270 | MetaboLights
Transcriptomicscis regulated role of lncRNA in transcriptional or developmental process (ChIRP-Seq)
We report that long noncoding RNAs contribute to transcription and developmental process. Thousands of lncRNAs have been identified in the whole genome, and tend to located closely to protein-coding genes. To study position relationship between lncRNA and protein-coding genes, we classified all of l...
ORGANISM(S): Mus musculus 
2016-03-24 | E-GEOD-79541 | biostudies-arrayexpress
UnknownQingxie Fuzheng granules attenuate cancer cachexia by restoring gut microbiota homeostasis and suppressing IL-6/NF-κB signaling in colorectal adenocarcinoma.
Not available
S-EPMC12398093 | biostudies-literature
TranscriptomicsRNA-Seq of human aortic endothelial cells with lysophosphatidylcholine, IL-35, and IL-10 against controls
Human aortic endothelial cells were stimulated by lysophosphatidylcholine (LPC) (10μM) with or without interleukin 35 (IL-35) (10ng/mL) or IL-10 (10ng/mL) for 18 hours. Total RNAs were extracted from samples, then mRNA and non-coding RNAs were enriched by removing rRNA from the total RNA. The libr...
ORGANISM(S): Homo sapiens 
2019-10-28 | E-MTAB-6604 | biostudies-arrayexpress
TranscriptomicsEvx1as and EVX1 knockouts by CRISPR
We report that long noncoding RNAs contribute to transcription and developmental process. Thousands of lncRNAs have been identified in the whole genome, and tend to located closely to protein-coding genes. To study position relationship between lncRNA and protein-coding genes, we classified all of l...
ORGANISM(S): Mus musculus 
2016-03-24 | E-GEOD-70419 | biostudies-arrayexpress
TranscriptomicsFunctional Plasticity of Regulatory T Cell Function
Regulatory T cells (Tregs) can suppress a wide variety of cell types, in diverse organ sites and inflammatory conditions. While Tregs possess multiple suppressive mechanisms, the number required for maximal function is unclear. Furthermore, whether any inter-relationship orcross-regulatory mechani...
ORGANISM(S): Mus musculus 
2011-12-08 | E-GEOD-29262 | biostudies-arrayexpress
ProteomicsTemporal proteomics characterization of COVID-19 patient sera
We enrolled 37 SARS-CoV-2 positive patients including 17 short course (SC) COVID-19 patients (twice viral RNA detection negative over 24 hrs) and 20 COVID-19 long course (LC) COVID-19 patients. We also included 35 SARS-CoV-2 negative patients as control group. We collected 224 inactive serum samples...
ORGANISM(S): Homo Sapiens 
2022-07-26 | PXD035471 |
Proteomics4E-BP1Ser37 phosphorylation associate with poor prognosis in HCC revealed by quantitative phosphoproteomics of portal vein tumor thrombus
Hepatocellular Carcinoma(HCC)is one of the most common malignat tumor,which is causing the second leading cancer-related death worldwide.
ORGANISM(S): Homo Sapiens 
2019-09-25 | PXD015570 |
Proteomicsaortic dissection molecular markers using iTRAQ combined with Label Free techniques
To screen serum molecular markers systematically amid aortic dissection and acute coronary syndrome, preliminary identify the pathogenesis of acute aortic dissection.
ORGANISM(S): Homo Sapiens 
2022-03-25 | PXD032857 |
ProteomicsEIF5A couples translational control with transcriptional reprogramming through chromocenter reorganization during spermiogenesis
Translation initiation factor eIF5A facilitates protein synthesis and impacts diverse biological processes, yet its role in transcriptional regulation is poorly understood. Here we find eIF5A highly expressed in diverse spermatogenic cell types. Conditional knockout of Eif5a (SKO) causes complete in...
ORGANISM(S): Mus Musculus 
2025-08-12 | PXD067244 |
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