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TranscriptomicsExpression analysis of Tim-3 knockdown RAW264.7 cell
Investigation of whole genome gene expression level changes in a Tim-3 knockdown RAW264.7 cell, compared to control siRNA transfected RAW264.7 cell. The Tim-3 knockdown of this cell render it hyper-reactive to TLR stimulation. Tim-3 knockdown analyzed in this study are further described in Li Y, Fen...
ORGANISM(S): Mus musculus 
2012-12-05 | E-GEOD-42729 | biostudies-arrayexpress
MetabolomicsNew insights into the responses of soil microorganisms to polycyclic aromatic hydrocarbon stress by combining enzyme activity and sequencing analysis with metabolomics
Polycyclic aromatic hydrocarbons (PAHs), some of the most widespread organic contaminants, are highly toxic to soil microorganisms. Whether long-term polluted soils can still respond to the fresh input of pollutants is unknown. In this study, the soil enzyme activity, soil microbial community struct...
2021-02-17 | MTBLS1196 | MetaboLights
TranscriptomicsDigital Gene Expression Tag Profiling after Wt1 deletion in Sertoli cell
The Wilms tumor gene, Wt1, is specifically expressed in Sertoli cells (SCs) which support spermatogenesis. Germ cell loss was found in Wt1 knockout mice. In vitro studies demonstrated that Wt1 was essential for cell polarity maintenance in SCs. We used Digital Gene Expression Tag Profili...
ORGANISM(S): Mus musculus 
2014-05-06 | E-GEOD-46664 | biostudies-arrayexpress
GenomicsGenome-wide survey of YY1 targets in C2C12 cells by High-throughput sequencing
By applying ChIP-seq, we generated genome-wide maps of YY1 in skeletal myoblasts and myotubes. We found that YY1 binds to 1820 confident target with a large portion residing in the intergenic regions. In addition, YY1 was found to activate many loci, and there is no significant overlap between YY1 a...
ORGANISM(S): Mus musculus 
2013-08-15 | E-GEOD-45875 | biostudies-arrayexpress
ProteomicsMass spec results of Tmc7-GST pull-down
For the GST pull-down of DRG ganglion, the GST- or Tmc7-GST-associated beads were further incubated with cell lysates derived from DRG ganglion. The pulled-down proteins were then separated by SDS-PAGE gel electrophoresis and subsequently stained with silver staining Kit. Finally, the target molecul...
ORGANISM(S): Mus Musculus 
2024-03-08 | PXD050466 |
ProteomicsSuccinyl-CoA synthetase deficiency in mouse forebrain results in hyper-succinylation with perturbed neuronal transcriptional regulation and metabolism
Lysine-succinylation is a subtype of protein acylation associated with metabolic regulation of succinyl-CoA in the TCA cycle. Deficiency of succinyl-CoA synthetase (SCS), the TCA-cycle enzyme catalyzing the reversible conversion of succinyl-CoA to succinate, leads to mitochondrial encephalomyopathy ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-06-21 | MSV000089697 | MassIVE
ProteomicsLockd promotes myoblast proliferation and skeletal muscle regeneration through binding with DHX36 to facilitate unwinding of 5’UTR rG4 and translation of Anp32e mRNA
Adult muscle stem cells, also known as satellite cells (SCs) play pivotal roles in injury induced muscle regeneration and our knowledge of long non-coding RNA (lncRNA) functions in SCs remains limited. Here we identify a lncRNA, Lockd which is induced in activated SCs upon acute muscle injury. We de...
ORGANISM(S): Mus Musculus 
2022-05-24 | PXD033658 |
ProteomicsMice CMECs TMT-based quantitative proteomic
Glucagon signaling blockade protects cardiac microvascular endothelial cells by inhibiting fatty acid β-oxidation and mitochondrial fusion
ORGANISM(S): Mus Musculus 
2021-08-12 | PXD027916 |
ProteomicsArginine methylation of METTL14 promotes RNA N6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells
m6A is the most abundant modification of mRNA in mammals and plays an important role in human development and disease. METTL14 is a key component of m6A methyltransferase complex. The project showed that its post-translational arginine methylation can regulate the generation of m6A and the endoderm ...
ORGANISM(S): Homo Sapiens 
2021-05-17 | PXD018458 |
ProteomicsProteomic analysis of rG4_A selectively degraded proteins through the proteasome
To explore the effects of rG4-PROTACs on the whole proteome, Hela cells were treated with blank (empty transfection control), rG4 mut_A, rG4_A, or rG4_A plus MG132, and a proteomic analysis was included in the subproject
ORGANISM(S): Homo Sapiens 
2024-11-21 | PXD058113 |
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