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ProteomicsProteome-wide analysis and functional identification of lysine β-hydroxybutyrylation in Ustilaginoidea virens
Lysine β-hydroxybutyrylation (Kbhb) is an evolutionarily conserved and widespread post-translational modification (PTM) in active gene transcription and cellular proliferation. However, its function remains unknown in phytopathogenic fungi. Here, we report a comprehensive identification of Kbhb in t...
ORGANISM(S): Ustilaginoidea virens 
2023-10-24 | PXD039304 | Pride
Lysine β-hydroxybutyrylation  post-translational modification  ustilaginoidea virens  virulence 
MetabolomicsProfiling the metabolome of uterine fluid for early detection of ovarian cancer

Ovarian cancer (OC) causes high mortality in women because of ineffective biomarkers for early diagnosis. Here, we perform metabolomics analysis on an initial training set of uterine fluid from 96 gynecological patients. A seven-metabolite-marker panel consisting of vanillylmandelic acid, norepin...

2023-03-06 | MTBLS4861 | MetaboLights
Proteomicsβ-Hydroxybutyrate Boosts Plant Immunity through Enhanced H3K9bhb Levels and Gene Expression Regulation
Although the functions of protein Kbhb have been widely studied in animal cells, however, the identification and functional characterization of this modification in plants remain unclear. Here, we identified 2,159 Kbhb sites on 1,128 proteins in rice flowers by Kbhb-proteomic analyses, serving as a ...
ORGANISM(S): Oryza sativa (Rice) 
2025-07-05 | PXD051126 | Pride
Lysine β-hydroxybutyrylation 
GenomicsGenome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer
The estrogen receptor alpha (ERa) drives the growth of two-thirds of all breast cancers. Endocrine therapy impinges on estrogen-induced ERa activation to block tumor growth. However, half of ERa-positive breast cancers are tolerant or acquire endocrine therapy resistance. Here we demonstrate that br...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-37323 | biostudies-arrayexpress
UnknownEvaluation of Differentially Expressed Genes in Leaves vs. Roots Subjected to Drought Stress in Flax (Linum usitatissimum L.).
Not available
S-EPMC10419004 | biostudies-literature
Proteomicsproteomic investigation of ovarian follicular fluid
To investigate the relationship between differentially expressed proteins in human ovarian follicular fluid representing oocyte maturation and quality.
ORGANISM(S): Homo Sapiens 
2021-07-26 | PXD027577 |
UnknownComprehensive Analysis of Differentially Expressed Genes and Epigenetic Modification-Related Expression Variation Induced by Saline Stress at Seedling Stage in Fiber and Oil Flax, Linum usitatissimum L.
Not available
S-EPMC9370232 | biostudies-literature
ProteomicsVIPAS39 confers ferroptosis resistance in ovarian cancer through exporting ACSL4
Ovarian cancer (OC), particularly its epithelial subtype (EOC), is the most lethal gynecological malignancy worldwide, with the majority of patients diagnosed at an advanced stage and a five-year survival rate below 30%. The standard treatment, primarily consisting of cytoreductive surgery and plati...
ORGANISM(S): Homo Sapiens 
2024-08-30 | PXD055446 |
ProteomicsTandem Mass Tag-based proteomics of astaxanthin-producing tobacco expressing astaxanthin synthetases from Adonis aestivalis
The synthesis of astaxanthin leads to growth retardation in tobacco. Meanwhile, irregular mosaic pigmentation randomly appears on the leaves of astaxanthin-producing tobacco. The purpose of this project is to elucidate the mechanism of growth retardation in astaxanthin-producing tobacco and to compa...
ORGANISM(S): Nicotiana Tabacum 
2024-03-05 | PXD050349 |
ProteomicsDown-regulated Glutathione Peroxidase-4 by Graphene Quantum Dots Inducing Ferroptosis in Macrophages
to explore the mechanism, we analyzed the differences in the protein profile of macrophages using tandem mass tags (TMT) proteomics.
ORGANISM(S): Mus Musculus 
2020-12-23 | PXD023303 |
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