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MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
MetabolomicsFFAR4-mediated IL-6 release from islet macrophages promotes insulin secretion and is compromised in type-2 diabetes

The function of islet macrophages is poorly understood. They promote glucose-stimulated insulin secretion (GSIS) in lean mice, however, the underlying mechanism has remained unclear. We show that activation of the free fatty acid receptor FFAR4 on islet macrophages leads to interleukin-6 (IL-6) r...

2026-08-19 | MTBLS12317 | MetaboLights
UnknownEfficacy and safety of Chinese patent medicines for allergic rhinitis based on 2020 Chinese Pharmacopoeia: a protocol for systematic review and meta-analysis of randomized controlled trials.
Not available
S-EPMC11934513 | biostudies-literature
UnknownAntithrombotic effects and related mechanisms of Salvia deserta Schang root EtOAc extracts.
Not available
S-EPMC6288089 | biostudies-literature
ProteomicsCell membrane remodeling mediates polymyxin B resistance in Klebsiella pneumoniae: an integrated proteomics and metabolomics study
In this study, resistance of Klebsiella pneumoniae (K. pneumoniae) to PB was induced by passaging in serial concentrations of PB. This study employed TMT-labeled quantitative proteomics and LC-MS/MS metabolomics analysis to investigate the key biological processes associated with PB resistance in K....
ORGANISM(S): Klebsiella pneumoniae LCT-KP289 
2022-01-24 | PXD030940 | Pride
Polymyxin b resistance Proteomics Metabolomics Klebsiella pneumoniae Membrane remodeling 
UnknownIdentification of FERMT1 and SGCD as key marker in acute aortic dissection from the perspective of predictive, preventive, and personalized medicine.
Not available
S-EPMC9727066 | biostudies-literature
UnknownMaternal circulating exosomal miR-185-5p levels as a predictive biomarker in patients with recurrent pregnancy loss.
Not available
S-EPMC10033820 | biostudies-literature
UnknownPhytochemical Characterization, Antioxidant Activity, and Anti-Melanoma Mechanism of Flower Buds of <i>Magnolia biondii</i> Pamp.
Not available
S-EPMC12157075 | biostudies-literature
MetabolomicsHuman umbilical cord-derived mesenchymal stem cells ameliorate perioperative neurocognitive disorder by inhibiting inflammatory responses and activating BDNF/TrkB/CREB signaling pathway in aged mice

BACKGROUND: Perioperative neurocognitive disorder (PND) is a key complication affecting older individuals after anesthesia and surgery. Failure to translate multiple pharmacological therapies for PND from preclinical studies to clinical settings has necessitated the exploration o...

2023-07-25 | MTBLS7759 | MetaboLights
UnknownJanus adhesive bio-patches with targeted drug delivery enabled anti-bacteria and pro-angiogenesis for dura mater repair.
Not available
S-EPMC11804716 | biostudies-literature
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