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ProteomicsEjection of mitochondria and TNF-α activation mediate hypertonicity-induced adipocytes dedifferentiation
Adipocyte extracellular vesicles and particles (EVs) proteomic profiling. In this study, we focus on the EVs proteomes changes induced by hypertonicity in 3T3-L1 and differentiated adipocytes. The source cells were cultured with isotonic/hypertonic medium for 48 hours, and EVs were isolated from the...
ORGANISM(S): Mus Musculus 
2023-10-20 | PXD046259 |
ProteomicsMAGL Targeted PROTAC Degrader Simultaneously Enhances P53 for Synergistic Treatment of Glioblastoma Stem Cell
This study focuses on the protein degradation effects of the MAGL inhibitor JZL184 and the newly synthesized MAGL-PROTAC on MAGL.
ORGANISM(S): Homo Sapiens 
2024-12-02 | PXD058506 |
ProteomicsProteome of human and mouse astrocytes and astrocyte-conditioned medium
Proteome of human and mouse astrocytes and astrocyte-conditioned medium
ORGANISM(S): Homo Sapiens Mus Musculus 
2025-02-05 | PXD060495 |
ProteomicsThe de novo design and synthesis of yeast chromosome XIII facilitates investigations on aging
In the era of synthetic biology, design, construction, and utilization of synthetic chromosomes with unique features provide a new strategy to study complex cellular processes such as aging. Herein, we successfully constructed the 884 Kb synXIII of Saccharomyces cerevisiae to investigate replicative...
ORGANISM(S): Saccharomyces Cerevisiae 
2024-10-30 | PXD057330 |
ProteomicsThe RNF214-TEAD-YAP signaling axis promotes hepatocellular carcinoma progression via TEAD ubiquitylation
We established an APEX proximity labeling strategy in coupled with mass spectrometry to identify interacting proteins of RNF214. In this approach, we first fused an engineered ascorbate peroxidase (APEX2) to either N-terminus or C-terminus of RNF214, expressed these two fusion proteins in HLF, an HC...
ORGANISM(S): Homo Sapiens 
2024-02-18 | PXD049453 |
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